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International Journal of Colorectal Disease

, Volume 14, Issue 3, pp 150–154 | Cite as

Short-chain fatty acids stimulate mucosal cell proliferation in the closed human rectum after Hartmann’s procedure

  • F. V. Mortensen
  • Niels C. Langkilde
  • Jens C. R. Joergensen
  • I. Hessov
Original Article

Abstract 

Hartmann’s procedure in humans results in a closed rectum deprived of its natural short-chain fatty acid source. This induces atrophy of the entire rectal wall. Ki-67 is a monoclonal antibody directed towards proteins in the cell nucleus that are present only during cell proliferation. This study investigated the effects of short-chain fatty acids on mucosal cell proliferation in the human rectum after Hartmann’s procedure by means of Ki-67. Eight patients in whom Hartmann’s procedure was performed were treated with placebo and then short-chain fatty acids for 14 days. Biopsies specimens were taken from the rectum before and after treatment; these were prepared with Ki-67 and labeling index was determined. The treatment was found significantly to increase proliferative activity in the rectal mucosa (P<0.01); the increase was principally in the middle (P<0.01) and upper crypt (P<0.05) compartments.

Key words Short chain fatty acids Hartmann’s procedure Ki-67 Labeling index Mucosal cell proliferation 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • F. V. Mortensen
    • 1
  • Niels C. Langkilde
    • 2
  • Jens C. R. Joergensen
    • 1
  • I. Hessov
    • 1
  1. 1.Department of Gastrointestinal Surgery L, Aarhus University Hospital, Tage Hansensgade 2, DK-8000 Aarhus C, Denmark, e-mail: F.V. Mortensen@Dadlnet.dk, Tel.: +45-8949-7575, Fax: +45-9849-7684DK
  2. 2.Department of Urology, Aarhus University Hospital, Tage Hansensgade 2, DK-8000 Aarhus C, DenmarkDK

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