International Journal of Colorectal Disease

, Volume 15, Issue 3, pp 144–160

Animal models of intestinal inflammation: new insights into the molecular pathogenesis and immunotherapy of inflammatory bowel disease

  • Stefan Wirtz
  • M. F. Neurath
Review

Abstract 

Inflammatory bowel diseases (IBDs) in humans are complex chronic inflammatory disorders of largely unknown cause. Several mouse models that in some respects resemble human IBDs have recently been developed and have provided new insights into immunoregulatory processes in the gut. Both genetic and environmental factors have been shown to be involved in chronic intestinal inflammation. In most of the models CD4+ T lymphocytes have been identified as central mediators of inflammation. Inappropriate activation of TH1-dominated cytokine pathways upon contact with luminal bacterial antigens and lack of tolerance appear to be crucial for intestinal pathology. We present a brief overview of important animal models of IBD and describe the recent progress in understanding the mechanisms that contribute to chronic intestinal inflammation. Furthermore, novel immunotherapeutic approaches derived from such animal models are discussed.

Keywords Inflammatory bowel disease Animal models Cytokines 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Stefan Wirtz
    • 1
  • M. F. Neurath
    • 1
  1. 1.Laboratory of Immunology, Medical Clinic I, University of Mainz, Langenbeckstrasse, 55101 Mainz, Germany Tel.: +49-6131-172374 Fax: +49-6131-175508DE

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