International Journal of Colorectal Disease

, Volume 34, Issue 12, pp 2171–2183 | Cite as

Preoperative short-course radiotherapy (5 × 5 Gy) with delayed surgery versus preoperative long-course radiotherapy for locally resectable rectal cancer: a meta-analysis

  • Wang Qiaoli
  • Huang Yongping
  • Xiong Wei
  • Xu Guoqiang
  • Ju Yunhe
  • Liu Qiuyan
  • Li Cheng
  • Guo Mengling
  • Li Jiayi
  • Xiong WeiEmail author
  • Yang YiEmail author
Original Article



Preoperative short-course radiotherapy (PSRT) and preoperative long-course radiotherapy (PLRT) are standard treatment regimens for locally advanced rectal cancer. However, whether the efficacy and safety of PSRT with delayed surgery (more than 4 weeks) are superior to those of PLRT remains unresolved and was explored in this meta-analysis.


Studies published in PubMed, Embase, the Cochrane Library, and databases were systematically searched. RevMan 5.3 was used to calculate pooled hazard ratios (HR) and relative risk (RR).


Seven studies including 4973 patients were identified in the meta-analysis. Pooled statistics showed that there was no statistically significant difference in overall survival (HR = 1.30, 95% CI 0.58–2.89, P = 0.52) or disease-free survival (HR = 1.10, 95% CI 0.73–1.66, P = 0.64) between the preoperative short-course and long-course radiotherapy groups. Moreover, pathological complete remission, early postoperative complications, treatment-related grade 3/4 toxicity, local recurrence, and distant metastasis were similar between the two groups. Interestingly, a subgroup analysis revealed that preoperative short-course radiotherapy without adjuvant chemotherapy not only resulted in lower treatment-related grade 3/4 toxicity than the long-course radiotherapy group (RR = 0.19, 95% CI 0.08–0.48, P < 0.01) but also resulted in significantly lower overall survival and pathological complete remission (P = 0.02, P < 0.01, respectively). Disappointingly, pooled statistics observed few advantages over long-course radiotherapy in short-course radiotherapy with the adjuvant chemotherapy subgroup.


PSRT with delayed surgery was as effective as PLRT for the management of locally resectable rectal cancer. However, not adding additional chemotherapy to PSRT not only significantly decreased grade 3/4 toxicity but also decreased pathological complete remission and overall survival.

Trial registration

The protocol for this meta-analysis was prospectively registered with PROSPERO (CRD42019133641)


Rectal cancer Preoperative short-course radiotherapy Preoperative long-course radiotherapy Adjuvant chemotherapy Meta-analysis 



The authors would like to thank Yunnan Cancer Hospital.

Funding information

This study received financial support from Kunming Medical University Cancer Radiation Therapy Technology Innovation Team Construction Project Funding and Funding for the “Ten Thousand Plan” Youth Talent Project in Yunnan Province.

Compliance with ethical standards

All the authors have complied with all applicable ethical standards.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Radiotherapy, Yunnan Cancer Hospitalthe Third Affiliated Hospital of Kunming Medical UniversityKunming CityChina
  2. 2.Department of Thoracic Surgery, Yunnan Cancer Hospitalthe Third Affiliated Hospital of Kunming Medical UniversityKunmingChina
  3. 3.Department of Cancer Colorectal Surgery, Yunnan Cancer Hospitalthe Third Affiliated Hospital of Kunming Medical UniversityKunmingChina
  4. 4.Yunnan Cancer Institute, Yunnan Cancer Hospitalthe Third Affiliated Hospital of Kunming Medical UniversityKunmingChina

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