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International Journal of Colorectal Disease

, Volume 34, Issue 2, pp 347–351 | Cite as

The role of the NOD2/CARD15 gene in surgical treatment prediction in patients with Crohn’s disease

  • L. Kunovsky
  • Z. Kala
  • F. MarekEmail author
  • J. Dolina
  • K. Poredska
  • L. Kucerova
  • K. Benesova
  • L. Mitas
Short Communication
  • 115 Downloads

Abstract

Purpose

Crohn’s disease (CD) belongs to chronic disorders with unpredictable disease course. The aim of this study was to identify how genetic testing (NOD2/CARD15) can be used in patients with CD to predict the need for surgical treatment (to define an aggressive type of disease where the patient can profit from early surgery).

Methods

The patients who were tested genetically had undergone a surgery due to CD at the Department of Surgery University Hospital Brno Bohunice between 2010 and 2016. The control group consisted of patients with CD who had been diagnosed with CD at least 5 years prior to the testing and had not required any surgical intervention. The second control group was healthy subjects.

Results

In total, there were 117 operated patients for CD, 77 patients with CD that had not undergone surgery for CD and 30 healthy subjects. For patients with at least one genetic mutation, the risk of the necessity of surgical treatment of CD is 1.96 times higher than for patients with no mutation. Patients with two or more mutations were generally operated on at a younger age, in a shorter time after being diagnosed and each patient had a partial resection of the ileum.

Conclusion

The group of operated patients with CD had a significantly higher distribution of at least one genetic mutation as opposed to the non-operated group. In patients with two or more mutations, the disease course was more aggressive. This group of patients might profit from the conservative top-down or early surgical therapy.

Keywords

Crohn’s disease Inflammatory bowel disease Disease course Genetics NOD2/CARD15 Surgery Intestinal resection Czech cohort 

Notes

Compliance with ethical standards

Ethical standard statement

All procedures which followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.

Informed consent

Informed consent was obtained from all patients for being included in the study.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of SurgeryUniversity Hospital Brno Bohunice, Faculty of Medicine, Masaryk UniversityBrnoCzech Republic
  2. 2.Department of GastroenterologyUniversity Hospital Brno Bohunice, Faculty of Medicine, Masaryk UniversityBrnoCzech Republic
  3. 3.Institute of Biostatistics and Analyses, Faculty of MedicineMasaryk UniversityBrnoCzech Republic
  4. 4.Institute of Health Information and Statistics of the Czech RepublicPragueCzech Republic

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