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International Journal of Colorectal Disease

, Volume 31, Issue 7, pp 1375–1376 | Cite as

Features of patients with inflammatory bowel diseases who develop hemophagocytic lymphohistiocytosis

  • Y. LiEmail author
  • C. F. Li
  • J. Zhang
  • X. F. Xia
  • L. Y. Zhou
  • J. J. Liu
  • Z. Q. Song
  • Y. M. Lv
  • A. Y. Wang
  • Y. P. Zhang
  • C. F. Liang
  • Y. Y. Shi
  • E. M. Quigley
  • Y. H. Huang
  • S. G. DingEmail author
Letter to the Editor

Dear Editor:

Hemophagocytic lymphohistiocytosis (HLH) is a serious hyperinflammatory condition that develops sporadically in patients undergoing treatment for inflammatory bowel disease (IBD). We collected data from a patient who developed HLH while undergoing treatment for IBD, as well as from 21 other cases through a literature search. We summarized clinical data, laboratory test results, imaging findings, and information on treatments and outcomes, and compared with the general IBD patients in two hospitals.

Altogether, 16 papers were collected. Most patients (20/22) were less than 45 years old, the male to female ratio was 12:10, and Crohn’s disease (CD):ulcerative colitis (UC) was 18:4. As for immunosuppressive regimen, nine patients were under thiopurines in monotherapy, in combination with steroids (n = 4) and infliximab (n = 4); three patients was on steroids monotherapy and one patient in combination with infliximab. Effectiveness of the immunosuppressive regimen was...

Keywords

Inflammatory Bowel Disease Infliximab Acute Pancreatitis Inflammatory Bowel Disease Patient Immunosuppressive Regimen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Y. Li
    • 1
    Email author
  • C. F. Li
    • 1
  • J. Zhang
    • 1
  • X. F. Xia
    • 2
  • L. Y. Zhou
    • 1
  • J. J. Liu
    • 4
  • Z. Q. Song
    • 1
  • Y. M. Lv
    • 1
  • A. Y. Wang
    • 1
  • Y. P. Zhang
    • 1
  • C. F. Liang
    • 1
  • Y. Y. Shi
    • 3
  • E. M. Quigley
    • 2
  • Y. H. Huang
    • 1
  • S. G. Ding
    • 1
    Email author
  1. 1.Department of GastroenterologyThe Third Hospital of Peking UniversityBeijingPeople’s Republic of China
  2. 2.Division of Gastroenterology and Hepatology, Department of Medicine, Houston Methodist HospitalWeill Cornell School of MedicineHoustonUSA
  3. 3.Research Center of Clinical EpidemiologyThe Third Hospital of Peking UniversityBeijingPeople’s Republic of China
  4. 4.Department of GastroenterologyThe Second Artillery General Hospital of Chinese Liberation ArmyBeijingPeople’s Republic of China

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