International Journal of Colorectal Disease

, Volume 31, Issue 3, pp 571–578 | Cite as

Long-term outcomes after treatment for T1 colorectal carcinoma

  • Naoki Asayama
  • Shiro OkaEmail author
  • Shinji Tanaka
  • Yuki Ninomiya
  • Yuzuru Tamaru
  • Kenjiro Shigita
  • Nana Hayashi
  • Hiroyuki Egi
  • Takao Hinoi
  • Hideki Ohdan
  • Koji Arihiro
  • Kazuaki Chayama
Original Article



Long-term outcomes of patients with T1 colorectal carcinoma (CRC) treated by endoscopic resection (ER) or surgical resection are unclear in relation to the curative criteria in the Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines. The aim of this study was to retrospectively compare the long-term outcomes among patients with T1 CRC in relation to the treatment methods.


We examined 322 T1 CRC cases treated between January 1992 and August 2008 at Hiroshima University Hospital. Patients who did not meet the curative criteria in the JSCCR guidelines were defined as “non-endoscopically curable” and classified into three groups: underwent ER alone (group A: 45 patients), underwent additional surgery after ER (group B: 106 patients), and underwent surgical resection alone (group C: 92 patients).


Of the 322 T1 CRC patients, 79 were categorized as endoscopically curable and 243 as non-endoscopically curable. Among the endoscopically curable T1 CRC patients, recurrence and 5-year OS rates were 0 and 94.2 %, respectively. In groups A, B, and C, recurrence rates were 4.4, 6.6, and 4.3 %, and OS rates were 85.6, 95.1, and 96.3 %, respectively (p < 0.05). Local recurrence or distant/lymph node metastasis was observed in 13 patients (group A: 2; group B: 7; group C: 4). Death due to primary CRC occurred in six patients (group B: 4; group C: 2).


Long-term outcomes support the curative criteria according to the JSCCR guidelines. ER for T1 CRC did not worsen clinical outcomes in cases that required additional surgical resection.


T1 colorectal carcinoma Treatment Recurrence Disease-free survival Overall survival 



The authors thank Professor Fumio Shimamoto at the Faculty of Human Culture and Science, Prefectural University of Hiroshima for advice on diagnosis of T1 CRC according to pathology.

Author contributions

NA, SO, and ST contributed to the study concept and design, statistical analysis and interpretation of data, and drafting of the manuscript. NA, YN, YT, KS, NH, HE, TH, and HO contributed to the acquisition of data. KA gave advice on diagnosis of T1 CRC according to pathology. All the authors participated in the critical revision of the article for important intellectual content and final approval of the article.

Compliance with ethical standards

The study protocol was approved by the Ethics Committee of Hiroshima University and was in keeping with the guidelines of the relevant government agency. All patients gave their informed consent before all procedures.

Conflict of interest

The authors declare that they have no competing interests.

Sources of funding



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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Naoki Asayama
    • 1
  • Shiro Oka
    • 2
    Email author
  • Shinji Tanaka
    • 2
  • Yuki Ninomiya
    • 1
  • Yuzuru Tamaru
    • 1
  • Kenjiro Shigita
    • 1
  • Nana Hayashi
    • 1
  • Hiroyuki Egi
    • 3
  • Takao Hinoi
    • 3
  • Hideki Ohdan
    • 3
  • Koji Arihiro
    • 4
  • Kazuaki Chayama
    • 1
  1. 1.Department of Gastroenterology and Metabolism, Graduate School of Biomedical SciencesHiroshima UniversityHiroshimaJapan
  2. 2.Department of EndoscopyHiroshima University HospitalHiroshimaJapan
  3. 3.Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health SciencesHiroshima UniversityHiroshimaJapan
  4. 4.Department of Anatomical PathologyHiroshima University HospitalHiroshimaJapan

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