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International Journal of Colorectal Disease

, Volume 31, Issue 2, pp 429–437 | Cite as

Effects of colonic electrical stimulation using different individual parameter patterns and stimulation sites on gastrointestinal transit time, defecation, and food intake

  • Shuo Chen
  • Liang Liu
  • Xiaojuan Guo
  • Shukun YaoEmail author
  • Yanmei LiEmail author
  • Shaoxuan Chen
  • Yanli Zhang
  • Wang Chen
  • Yuhui Du
Original Article

Abstract

Purpose

This study aimed to compare the effects of colonic electrical stimulation (CES) on gastrointestinal transit time (GITT), energy consumption, stool frequency, stool consistency, and food intake using different individual parameter patterns and stimulation sites.

Methods

Eight beagle dogs underwent surgery and CES. First, CES was conducted to determine the individual parameters with different pulse configurations, based on symptoms. Second, influences on energy consumption and GITT were compared between CES sessions with different pulse configurations. Third, GITT, stool frequency, stool consistency, and food intake were compared to assess the effects of CES at different stimulation sites.

Results

The individual parameters varied greatly among the dogs. In proximal colon electrical stimulation (PCES) and rectosigmoid colon electrical stimulation (RCES), energy consumption was lower with the constant pulse width mode than with the constant pulse amplitude mode (p = 0.012 and p = 0.018, respectively). There was no statistical difference between the two pulse configurations in GITT assessment. The PCES, RCES, and sequential CES sessions significantly accelerated GITT compared to sham stimulation. There was no statistical difference in GITT between PCES, RCES, and sequential CES sessions. Compared to sham CES session, RCES and sequential CES sessions exhibited significant higher stool frequency (p < 0.001 and p = 0.001, respectively), and PCES and RCES sessions inhibited food intake (p = 0.003 and p = 0.002, respectively).

Conclusions

Constant pulse width mode is an appropriate pulse configuration for individual CES. At different stimulation sites, CES may exert different effects on stool frequency and food intake. This study provides an experimental basis for the clinical application of CES.

Keywords

Colonic electrical stimulation Constipation Individual parameter selection Gastrointestinal transit time 

Notes

Acknowledgments

This work was supported by the National High-tech R&D Program (863 Program) (grant no. 2012AA021104) and the National Natural Science Foundation of China (grant no. 81070299).

Compliance with ethical standards

All procedures performed in this study were in accordance with the ethical standards of the China–Japan Friendship Hospital (Beijing, China).

Conflict of interest

The authors declared no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Shuo Chen
    • 1
    • 2
  • Liang Liu
    • 3
  • Xiaojuan Guo
    • 4
  • Shukun Yao
    • 1
    • 2
    Email author
  • Yanmei Li
    • 1
    Email author
  • Shaoxuan Chen
    • 1
  • Yanli Zhang
    • 1
  • Wang Chen
    • 5
  • Yuhui Du
    • 6
  1. 1.Department of GastroenterologyChina–Japan Friendship HospitalChaoyang District, BeijingPeople’s Republic of China
  2. 2.Graduate SchoolPeking Union Medical College and Chinese Academy of Medical SciencesDongcheng District, BeijingPeople’s Republic of China
  3. 3.Department of GastroenterologyJinan Central Hospital Affiliated to Shandong UniversityLixia District, JinanPeople’s Republic of China
  4. 4.Department of GastroenterologyBeijing Tsinghua Chang Gung HospitalChangping District, BeijingPeople’s Republic of China
  5. 5.Institute of Clinical MedicineChina-Japan Friendship HospitalChaoyang District, BeijingPeople’s Republic of China
  6. 6.Rishena Technology Development Co. Ltd.Xinbei District, ChangzhouPeople’s Republic of China

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