International Journal of Colorectal Disease

, Volume 31, Issue 6, pp 1251–1252 | Cite as

Calcium alginate as a rectal bulking agent. Experimental pilot study to determine its migratory trend and locoregional reaction

  • Fernando de la Portilla
  • F. De Marco
  • M. Molero
  • M. A. Sánchez-Hurtado (MA Sánchez-Hurtado)
  • S. Pereira
Letter to the Editor

Dear Editor:

Faecal incontinence affects an estimated 2 % of the population. Most patients can be treated either conservatively or by surgical repair if there is a physical disruption of the anal sphincter.

A minimally invasive approach involving the injection of a bulking agent either around the IAS or into a defect in the IAS is a simple option for the treatment of this condition, and various materials have been tested to that end. Ideally, a filling material should be easy to inject, biocompatible, non-carcinogenic, non-immunogenic, and should induce minimal inflammatory and fibrotic responses. The agent particles should be big enough to avoid migration away from the injection site (diameter >80 μm), but they should be durable enough to last for a sufficient length of time.

Several newly applied materials consisting of natural or synthetic polymers appear to be as efficacious as the therapies currently employed, but extensive long-term data are not yet available.

Alginates are a...


Methylene Blue Faecal Incontinence Calcium Alginate Calcium Gluconate Alginate Hydrogel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Compliance with ethical standards

All experimental procedures were performed according to PHS and IACUC guidelines.

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Fernando de la Portilla
    • 1
    • 5
  • F. De Marco
    • 2
  • M. Molero
    • 3
  • M. A. Sánchez-Hurtado (MA Sánchez-Hurtado)
    • 4
  • S. Pereira
    • 2
  1. 1.Departmento de Cirugía General y Digestiva, Unidad de ColoproctologíaHospital Universitario “Virgen del Rocío”/IBiS/CSIC/University of SevilleSevillaSpain
  2. 2.Institute of Biomedicine of Seville (IBiS)“Virgen del Rocío” University Hospital/IBiS/CSIC/University of SevilleSevilleSpain
  3. 3.Department of Physical Chemistry, Faculty of ChemistryUniversity of SevilleSevillaSpain
  4. 4.Jesús Usón Minimally Invasive Surgery CentreCaceresSpain
  5. 5.Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD o Ciberehd), Instituto de Salud Carlos IIIMadridSpain

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