Calcium alginate as a rectal bulking agent. Experimental pilot study to determine its migratory trend and locoregional reaction
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Faecal incontinence affects an estimated 2 % of the population. Most patients can be treated either conservatively or by surgical repair if there is a physical disruption of the anal sphincter.
A minimally invasive approach involving the injection of a bulking agent either around the IAS or into a defect in the IAS is a simple option for the treatment of this condition, and various materials have been tested to that end. Ideally, a filling material should be easy to inject, biocompatible, non-carcinogenic, non-immunogenic, and should induce minimal inflammatory and fibrotic responses. The agent particles should be big enough to avoid migration away from the injection site (diameter >80 μm), but they should be durable enough to last for a sufficient length of time.
Several newly applied materials consisting of natural or synthetic polymers appear to be as efficacious as the therapies currently employed, but extensive long-term data are not yet available.
Alginates are a...
KeywordsMethylene Blue Faecal Incontinence Calcium Alginate Calcium Gluconate Alginate Hydrogel
Compliance with ethical standards
All experimental procedures were performed according to PHS and IACUC guidelines.