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International Journal of Colorectal Disease

, Volume 30, Issue 8, pp 1015–1028 | Cite as

Stage-specific frequency and prognostic significance of aneuploidy in patients with sporadic colorectal cancer—a meta-analysis and current overview

  • Tilman Laubert
  • Sandra Freitag-Wolf
  • Michael Linnebacher
  • Alexandra König
  • Brigitte Vollmar
  • Jens K. Habermann
  • on behalf of the North German Tumorbank of Colorectal Cancer (ColoNet) consortium
Original Article

Abstract

Purpose

Aneuploidy has long been suggested as an independent prognostic marker for colorectal cancer (CRC) patients and could thus aid for individualized medicine. However, due to a large spectrum of deviating studies, expert panels do not recommend ploidy assessment. In order to clarify a potential bias of stage-specific frequency of aneuploidy, we now conducted a meta-analysis combined with a systematic review regarding aneuploidy and prognosis.

Methods

A systematic, web-based search process retrieved 1935 studies published in English between 1990 and 2011. The defined endpoint for the meta-analysis was an increase in aneuploidy frequency between early- (Dukes A, B and UICC I, II; n = 3632 samples) and late-stage (Dukes C, D and UICC III, IV; n = 3440 samples) colorectal carcinomas.

Results

Of 1935 studies initially identified, 17 image (2130 patients) and 20 (7023 patients) flow cytometric studies were analyzed in detail. The meta-analysis (7072 patients) revealed late-stage CRC to be more frequently aneuploid than early-stage CRC (odds ratio 1.51, 95 % CI 1.37–1.67; p = 0.0007). Independent of tumor stage, the overall range of aneuploidy was 39 to 81 % (median 58 %), and altogether, 21 (54.1 %) studies described a significant prognostic impact of aneuploidy for overall, disease-specific, and recurrence-free survival, respectively.

Conclusions

A substantial number of studies showed a prognostic importance of aneuploidy in CRC. Furthermore, the higher frequency of aneuploidy in late-stage CRC implies an increase in genomic instability with CRC progression, indicating aneuploidy to be also a stage-specific prognostic marker.

Keywords

Colorectal cancer Aneuploidy Prognosis Chromosomal instability Meta-analysis 

Notes

Acknowledgments

Grants from the Ad Infinitum Foundation, the Werner & Clara Kreitz Foundation and the H.W. & J. Hector Foundation are gratefully acknowledged. This review was performed by the North German Tumorbank of Colorectal Cancer (ColoNet) being generously funded by the German Cancer Aid Foundation (DKH #108446) and in collaboration with the Surgical Center for Translational Oncology – Lübeck (SCTO-L).

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Tilman Laubert
    • 1
  • Sandra Freitag-Wolf
    • 2
  • Michael Linnebacher
    • 3
  • Alexandra König
    • 4
  • Brigitte Vollmar
    • 5
  • Jens K. Habermann
    • 1
  • on behalf of the North German Tumorbank of Colorectal Cancer (ColoNet) consortium
  1. 1.Section of Translational Surgical Oncology and Biobanking, Department of SurgeryUniversity of Lübeck and University Medical Center Schleswig-HolsteinLübeckGermany
  2. 2.Institute of Medical Informatics and StatisticsUniversity Medical Center Schleswig-HolsteinKielGermany
  3. 3.Devision of Molecular Oncology and Immunotherapy, Department of General SurgeryUniversity of RostockRostockGermany
  4. 4.Department of General, Visceral and Thoracic SurgeryUniversity Clinic Hamburg-EppendorfHamburgGermany
  5. 5.Institute for Experimental Surgery and Central Animal Research FacilityUniversity of RostockRostockGermany

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