International Journal of Colorectal Disease

, Volume 30, Issue 8, pp 1015–1028 | Cite as

Stage-specific frequency and prognostic significance of aneuploidy in patients with sporadic colorectal cancer—a meta-analysis and current overview

  • Tilman Laubert
  • Sandra Freitag-Wolf
  • Michael Linnebacher
  • Alexandra König
  • Brigitte Vollmar
  • Jens K. Habermann
  • on behalf of the North German Tumorbank of Colorectal Cancer (ColoNet) consortium
Original Article
First Online:
Accepted:

Abstract

Purpose

Aneuploidy has long been suggested as an independent prognostic marker for colorectal cancer (CRC) patients and could thus aid for individualized medicine. However, due to a large spectrum of deviating studies, expert panels do not recommend ploidy assessment. In order to clarify a potential bias of stage-specific frequency of aneuploidy, we now conducted a meta-analysis combined with a systematic review regarding aneuploidy and prognosis.

Methods

A systematic, web-based search process retrieved 1935 studies published in English between 1990 and 2011. The defined endpoint for the meta-analysis was an increase in aneuploidy frequency between early- (Dukes A, B and UICC I, II; n = 3632 samples) and late-stage (Dukes C, D and UICC III, IV; n = 3440 samples) colorectal carcinomas.

Results

Of 1935 studies initially identified, 17 image (2130 patients) and 20 (7023 patients) flow cytometric studies were analyzed in detail. The meta-analysis (7072 patients) revealed late-stage CRC to be more frequently aneuploid than early-stage CRC (odds ratio 1.51, 95 % CI 1.37–1.67; p = 0.0007). Independent of tumor stage, the overall range of aneuploidy was 39 to 81 % (median 58 %), and altogether, 21 (54.1 %) studies described a significant prognostic impact of aneuploidy for overall, disease-specific, and recurrence-free survival, respectively.

Conclusions

A substantial number of studies showed a prognostic importance of aneuploidy in CRC. Furthermore, the higher frequency of aneuploidy in late-stage CRC implies an increase in genomic instability with CRC progression, indicating aneuploidy to be also a stage-specific prognostic marker.

Keywords

Colorectal cancer Aneuploidy Prognosis Chromosomal instability Meta-analysis 
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Notes

Acknowledgments

Grants from the Ad Infinitum Foundation, the Werner & Clara Kreitz Foundation and the H.W. & J. Hector Foundation are gratefully acknowledged. This review was performed by the North German Tumorbank of Colorectal Cancer (ColoNet) being generously funded by the German Cancer Aid Foundation (DKH #108446) and in collaboration with the Surgical Center for Translational Oncology – Lübeck (SCTO-L).

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Tilman Laubert
    • 1
  • Sandra Freitag-Wolf
    • 2
  • Michael Linnebacher
    • 3
  • Alexandra König
    • 4
  • Brigitte Vollmar
    • 5
  • Jens K. Habermann
    • 1
  • on behalf of the North German Tumorbank of Colorectal Cancer (ColoNet) consortium
  1. 1.Section of Translational Surgical Oncology and Biobanking, Department of SurgeryUniversity of Lübeck and University Medical Center Schleswig-HolsteinLübeckGermany
  2. 2.Institute of Medical Informatics and StatisticsUniversity Medical Center Schleswig-HolsteinKielGermany
  3. 3.Devision of Molecular Oncology and Immunotherapy, Department of General SurgeryUniversity of RostockRostockGermany
  4. 4.Department of General, Visceral and Thoracic SurgeryUniversity Clinic Hamburg-EppendorfHamburgGermany
  5. 5.Institute for Experimental Surgery and Central Animal Research FacilityUniversity of RostockRostockGermany

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