International Journal of Colorectal Disease

, Volume 29, Issue 4, pp 519–527 | Cite as

Do young patients have different clinical presentation of colorectal cancer causing delay in diagnosis?

  • João Batista de Sousa
  • Caio Simões Souza
  • Maria Bianca Fernandes
  • Leonardo de Castro Durães
  • Romulo Medeiros de Almeida
  • Antônio Carlos Nóbrega dos Santos
  • Eduardo Freitas da Silva
  • Paulo Gonçalves de Oliveira
Original Article

Abstract

Purpose

The incidence of colorectal cancer is increasing among young patients. In these patients, colorectal cancer is believed to have a poorer prognosis because it is more aggressive and diagnosed at later stages; however, the behavior of these tumors in young patients remains to be elucidated. We investigated the impact of time interval between onset of symptoms and diagnosis (TISD) at the pathologic stage of colorectal cancer in young patients.

Methods

The medical records of 215 patients with colorectal adenocarcinoma were reviewed. Patients were divided into two groups according to age. The young group (age < 50 years) consisted of 66 patients, and the older group (age ≥ 50 years) of 149 patients. Clinical variables, TISD, pathologic stage, operative mortality, and oncologic outcomes were compared between groups.

Results

The older group had less abdominal pain (74.0 vs. 56.0 %, p = 0.0129). In multivariate analysis, the following variables were independently associated with tumor pathologic stage: personal history of inflammatory bowel disease (p < 0.0001), family history of familial adenomatous polyposis (p = 0.00100), and smoking (p = 0.0070). Both groups had similar rates regarding pathologic stage (I, 15 vs. 22 %; II, 22 vs. 24 %; III, 27 vs. 16 %; IV, 37 vs. 38 %, p = 0.3380). There was no difference in overall survival [45 (69 %) vs. 84 (61 %), p = 0.2482] and cancer-free survival [36 (63 %) vs. 83 (62 %), p = 0.9218] between groups.

Conclusions

Young patients with colorectal cancer had clinical and pathological presentation similar to that of older patients.

Keywords

Colorectal cancer Young patients Colorectal cancer in young patients Diagnosis Clinical presentation TNM staging 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • João Batista de Sousa
    • 1
    • 2
    • 5
  • Caio Simões Souza
    • 1
  • Maria Bianca Fernandes
    • 3
  • Leonardo de Castro Durães
    • 1
  • Romulo Medeiros de Almeida
    • 1
    • 2
  • Antônio Carlos Nóbrega dos Santos
    • 1
  • Eduardo Freitas da Silva
    • 4
  • Paulo Gonçalves de Oliveira
    • 1
    • 2
  1. 1.Coloproctology Service, Hospital Universitário de BrasíliaUniversidade de Brasília, Center of Surgical ClinicsBrasíliaBrazil
  2. 2.Division of Surgery, School of MedicineUniversidade de BrasíliaBrasíliaBrazil
  3. 3.State Department of Health of the Federal DistrictBrasíliaBrazil
  4. 4.Department of Statistics, Institute of Exact SciencesUniversidade de BrasíliaBrasíliaBrazil
  5. 5.Secretaria do Centro de Clínicas CirúrgicasHospital Universitário de BrasíliaBrasíliaBrazil

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