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International Journal of Colorectal Disease

, Volume 29, Issue 2, pp 267–269 | Cite as

Rice bran oil and n-3 fatty acid-rich garden cress (Lepidium sativum) seed oil attenuate murine model of ulcerative colitis

  • K. Vijay Kumar Reddy
  • A. Maheswaraiah
  • K. Akhilender NaiduEmail author
Letter to the Editor

Dear Editor:

Ulcerative colitis (UC) is an autoimmune disease of humans characterized by chronic inflammation in the colon and rectum. Although the etiology and pathogenesis of UC remain unclear, there is increasing evidence that the dysregulation of mucosal immunological function plays a major role in the initiation and propagation of this disease. Data on the previous studies suggest that the overproduction of pro-inflammatory cytokines such as interleukin-1β (IL-1β), interferon-γ, and tumor necrosis factor-α (TNF-α) and inflammatory mediators such as nitric oxide (NO), superoxide, and leukotriene B4 (LTB4) result in inflammation which may subsequently cause mucosal damage and ulceration of the colon. Current therapies for UC usually include 5-aminosalicylic acid, sulfasalazine, and glucocorticoids, which can inhibit the related inflammatory mediators. However, the adverse reactions following prolonged treatment limit their clinical application. Therefore, there is an urgent need to...

Keywords

Ulcerative Colitis Dextran Sulfate Sodium LTB4 Tocotrienols Oryzanol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • K. Vijay Kumar Reddy
    • 1
  • A. Maheswaraiah
    • 1
  • K. Akhilender Naidu
    • 1
    Email author
  1. 1.Department of Biochemistry and NutritionCSIR-Central Food Technological Research InstituteMysoreIndia

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