Rice bran oil and n-3 fatty acid-rich garden cress (Lepidium sativum) seed oil attenuate murine model of ulcerative colitis
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Ulcerative colitis (UC) is an autoimmune disease of humans characterized by chronic inflammation in the colon and rectum. Although the etiology and pathogenesis of UC remain unclear, there is increasing evidence that the dysregulation of mucosal immunological function plays a major role in the initiation and propagation of this disease. Data on the previous studies suggest that the overproduction of pro-inflammatory cytokines such as interleukin-1β (IL-1β), interferon-γ, and tumor necrosis factor-α (TNF-α) and inflammatory mediators such as nitric oxide (NO), superoxide, and leukotriene B4 (LTB4) result in inflammation which may subsequently cause mucosal damage and ulceration of the colon. Current therapies for UC usually include 5-aminosalicylic acid, sulfasalazine, and glucocorticoids, which can inhibit the related inflammatory mediators. However, the adverse reactions following prolonged treatment limit their clinical application. Therefore, there is an urgent need to...
KeywordsUlcerative Colitis Dextran Sulfate Sodium LTB4 Tocotrienols Oryzanol