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International Journal of Colorectal Disease

, Volume 28, Issue 9, pp 1203–1208 | Cite as

Neuroendocrine markers and psychological features in patients with irritable bowel syndrome

  • Cristina StasiEmail author
  • Massimo Bellini
  • Francesco Costa
  • Maria Gloria Mumolo
  • Angelo Ricchiuti
  • Mariano Grosso
  • Emiliano Duranti
  • Maria Rosaria Metelli
  • Dario Gambaccini
  • Lea Bianchi
  • Gian Luca Di Tanna
  • Giacomo Laffi
  • Stefano Taddei
  • Santino Marchi
Original Article

Abstract

Background and aims

The key role of the brain-gut axis in the pathophysiology of irritable bowel syndrome (IBS) has been recognized. The aim of this study was to assess the possible association between IBS, neuroendocrine markers, and psychological features.

Methods

One hundred and twenty-five consecutive IBS patients and 105 healthy subjects were enrolled. Plasma serotonin, plasma and urinary cortisol, and plasma neuropeptide Y levels were evaluated. All patients were given a questionnaire to assess IBS symptom severity. In 66 patients, a psychodiagnostic assessment was carried out.

Results

A high incidence of specific psychological features, including state anxiety (69.69 %), trait anxiety (54.54 %), obsessions and compulsions (28.78 %), was observed in IBS patients. A positive correlation between neuropeptide Y and state anxiety (r = 0.287, p = 0.024) and simulation/social ingenuity (r = 0.269, p = 0.039) was found in these patients. In diarrhea-predominant IBS, plasma cortisol was linearly related to plasma serotonin (r = 0.5663, p < 0.001).

Conclusions

In IBS patients, a significant correlation was found between specific psychological features and neuroendocrine markers, especially plasma cortisol and neuropeptide Y; in diarrhea-predominant IBS, a correlation between plasma cortisol and serotonin was found, although it needs to be confirmed in more extensive cohorts.

Keywords

Neuroendocrine markers Psychological features Irritable bowel syndrome 

Abbreviations

NPY

Neuropeptide Y

IBS

Irritable bowel syndrome

HS

Healthy subjects

Notes

Conflict of interest

The authors have no conflicts of interest to disclose.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Cristina Stasi
    • 1
    • 8
    Email author
  • Massimo Bellini
    • 2
  • Francesco Costa
    • 2
  • Maria Gloria Mumolo
    • 2
  • Angelo Ricchiuti
    • 2
  • Mariano Grosso
    • 3
  • Emiliano Duranti
    • 4
  • Maria Rosaria Metelli
    • 5
  • Dario Gambaccini
    • 2
  • Lea Bianchi
    • 6
  • Gian Luca Di Tanna
    • 7
  • Giacomo Laffi
    • 1
  • Stefano Taddei
    • 4
  • Santino Marchi
    • 2
  1. 1.Department of Internal MedicineUniversity of FlorenceFlorenceItaly
  2. 2.Gastroenterology Unit, Department of GastroenterologyUniversity of PisaPisaItaly
  3. 3.Regional Center of Nuclear MedicineUniversity of PisaPisaItaly
  4. 4.Department of Internal MedicineUniversity of PisaPisaItaly
  5. 5.Laboratory of Clinical Biochemistry and Molecular BiologyUniversity of PisaPisaItaly
  6. 6.Laboratory of Chemistry and EndocrinologyUniversity of PisaPisaItaly
  7. 7.Department of Public Health and Infectious DiseasesSapienza University of RomeRomeItaly
  8. 8.Dipartimento di Medicina InternaFirenzeItaly

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