Prevalence and risk factors for colonic perforation during colonoscopy in hospitalized end-stage renal disease patients on hemodialysis
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Background and aims
Colonic perforation is a rare complication during colonoscopy. A recent single center study reported a high incidence of colonic perforation in end-stage renal disease (ESRD) patients on hemodialysis (HD) who underwent colonoscopy. We sought to determine nationwide, population-based prevalence in rates of colonic perforation during colonoscopy among ESRD inpatients on HD in the US, and to assess risk factors for colonic perforation in this patient population.
We obtained patient data from the Nationwide Inpatient Sample and used the International Classification of Diseases, the 9th revision, clinical modification codes, to identify ESRD patients on HD who had undergone colonoscopy in 2006. The control group consisted of inpatients who had colonoscopy without ESRD.
Colonic perforations occurred in 51/17,000 ESRD hospitalizations on HD (0.3%) and 3,951/564,428 controls without ESRD (0.7%). The risk of colonic perforation among the study group was not significantly higher than the control group even after adjusting for patient demographics like age, gender and comorbid conditions (adjusted odds ratio [aOR] −0.55; 95% confidence interval [CI], 0.30–0.97). Older age (OR −1.007; 95% CI, 1.002–1.011) and female gender (OR −1.18; 95% CI, 1.03–1.36) were identified as independent risk factors for the risk of perforation in this population group.
There appeared no increased risk of colonic perforation during colonoscopy among inpatients who received HD in our study. Increasing age and female patients appeared to be associated with procedure-related colonic perforation.
KeywordsColonic perforation Colonoscopy End-stage renal disease Hemodialysis
Charlson comorbidity index
End-stage renal disease
Healthcare cost and utilization project
Nationwide inpatient sample
Conflict of interest
None of the authors declare any commercial conflict of interest.
Study concept, data monitoring, paper preparation and revisions—U. Navaneethan
Data monitoring and paper preparation—Preethi G.K. Venkatesh
Data monitoring and statistical analysis—Sravanthi Parasa
Study design, study concept and paper revisions—Bo Shen
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