International Journal of Colorectal Disease

, Volume 25, Issue 4, pp 491–498 | Cite as

Colloid vs. crystalloid infusions in gastrointestinal surgery and their different impact on the healing of intestinal anastomoses

  • Goran MarjanovicEmail author
  • Christian Villain
  • Sylvia Timme
  • Axel zur Hausen
  • Jens Hoeppner
  • Frank Makowiec
  • Philipp Holzner
  • Ulrich Theodor Hopt
  • Robert Obermaier
Original Article



The aim of this study was to investigate if colloid infusions have different effects on intestinal anastomotic healing when compared to crystalloid infusions depending on the amount of the administered volume.

Materials and methods

Twenty-eight Wistar rats were randomly assigned to four groups receiving different amounts of either a crystalloid (Cry) or a colloid (Col) infusion solution. Animals with volume restriction (Cry (−) or Col (−)) were treated with a low and animals with volume overcharge (Cry (+) or Col (+)) with a high flow rate. All animals received an infusion for a 60-min period, while an end-to-end small bowel anastomosis was performed. At reoperation, the anastomotic bursting pressure (millimeters of mercury) was measured, as well as anastomotic hydroxyproline concentration. The presence of bowel wall edema was assessed histologically.


Median bursting pressures were comparable in the Col (−) [118 mm Hg (range 113–170)], the Cry (−) [118 mm Hg (78–139)], and the Col (+) [97 mm Hg (65–152)] group. A significantly lower median bursting pressure was found in animals with crystalloid volume overload Cry (+) [73 mm Hg (60–101)]. Corresponding results were found for hydroxyproline concentration. Histology revealed submucosal edema in Cry (+) animals.


In case of a fixed, high-volume load, colloids seem to have benefits on intestinal anastomotic healing when compared to crystalloid infusions.


Colloids Fluid management Intestinal anastomosis Anastomotic stability Fluid regime 


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Goran Marjanovic
    • 1
    • 3
    Email author
  • Christian Villain
    • 3
  • Sylvia Timme
    • 2
  • Axel zur Hausen
    • 2
  • Jens Hoeppner
    • 3
  • Frank Makowiec
    • 3
  • Philipp Holzner
    • 3
  • Ulrich Theodor Hopt
    • 3
  • Robert Obermaier
    • 3
  1. 1.Department of SurgeryUniversity of FreiburgFreiburgGermany
  2. 2.Institute of PathologyUniversity of FreiburgFreiburgGermany
  3. 3.Department of General and Digestive SurgeryUniversity of FreiburgFreiburgGermany

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