International Journal of Colorectal Disease

, Volume 24, Issue 7, pp 777–788

Survival, surgical management and perioperative mortality of colorectal cancer in the 21-year experience of a specialised registry

  • Maurizio Ponz de Leon
  • Annalisa Pezzi
  • Piero Benatti
  • Antonio Manenti
  • Giuseppina Rossi
  • Carmela di Gregorio
  • Luca Roncucci
Original Article

DOI: 10.1007/s00384-009-0687-1

Cite this article as:
de Leon, M.P., Pezzi, A., Benatti, P. et al. Int J Colorectal Dis (2009) 24: 777. doi:10.1007/s00384-009-0687-1

Abstract

Background and aims

A general improvement of colorectal cancer prognosis has been observed. Reasons of this more favourable trend are diffusion of screening, advancements in molecular biology, new developments in chemotherapy and surgical techniques. Through the data of a colorectal cancer registry, we purposed to evaluate changes in surgical procedures for colorectal neoplasms and to analyse trends of perioperative mortality.

Patients and methods

Patients with colorectal cancer were registered from 1984 to 2004. The main surgical procedures were recorded and classified. Perioperative mortality was defined as death of patients within 1 month since the operation.

Results

Regression analysis showed an increase over time of right and left hemicolectomy. Both colectomy and endoscopic polypectomy showed significant rise over time. In contrast, abdominoperineal operations dropped during the study period. A similar decrease was observed for palliative surgery. Perioperative mortality declined from 7–11% to 3–6% of all operations; main factors associated with perioperative mortality were presence of comorbidities, increasing age and advanced stage.

Conclusion

The better prognosis of patients with colorectal cancer was associated with changes of surgical techniques, with a tendency to prefer large operations over limited resections. Perioperative mortality showed a gradual decrease and is at present in the order of 3% to 6% of all operations.

Keywords

Colon Rectum Cancer Tumour Perioperative mortality 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Maurizio Ponz de Leon
    • 1
  • Annalisa Pezzi
    • 1
  • Piero Benatti
    • 1
  • Antonio Manenti
    • 2
  • Giuseppina Rossi
    • 1
  • Carmela di Gregorio
    • 3
  • Luca Roncucci
    • 1
  1. 1.Dipartimento di Medicina InternaUniversità di Modena e Reggio EmiliaModenaItaly
  2. 2.Dipartimento di ChirurgiaUniversità di Modena e Reggio EmiliaModenaItaly
  3. 3.Divisione di Anatomia PatologicaOspedale di CarpiModenaItaly

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