International Journal of Colorectal Disease

, Volume 22, Issue 9, pp 1031–1036 | Cite as

Microscopic colitides: a single center experience in Mexico

  • Alberto Rubio-Tapia
  • Julio Martínez-Salgado
  • Jorge García-Leiva
  • Braulio Martínez-Benítez
  • Misael Uribe
Original Article



Microscopic colitis is characterized by chronic diarrhea and specific microscopic changes in a macroscopically normal colonic mucosa. In this paper, we report the clinical and histological features of a group of Mexican patients with microscopic colitis.

Materials and methods

Patients were identified from 10 years of data in the pathology database of our institution. A pathologist reassessed all biopsy material. We included only patients who met strict histopathological criteria. Clinical data were obtained from medical records.


Microscopic colitis was diagnosed in 26 cases. The female/male ratio was 1.8:1. The median age at diagnosis was 56.5 ± 15.7 (range, 26–85) years. The most frequent symptoms were diarrhea in all, weight loss in 22 (84%), and abdominal pain in 18 (69%) patients. Sixteen (61%) patients reported associated diseases; autoimmune thyroid disorders were the most common. Drug-induced microscopic colitis was suspected in 12 (46%) patients. More than 80% of the treated patients improved or had clinical remission.


Microscopic colitis is an uncommon colonic disease at our institution, representing less than 1% of the final diagnoses in mucosal colonic biopsies. It is the largest case series of microscopic colitis in the Mexican population.


Microscopic colitis Lymphocytic colitis Collagenous colitis 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Alberto Rubio-Tapia
    • 1
  • Julio Martínez-Salgado
    • 1
  • Jorge García-Leiva
    • 1
  • Braulio Martínez-Benítez
    • 2
  • Misael Uribe
    • 1
  1. 1.Department of GastroenterologyInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INNSZ)Mexico CityMexico
  2. 2.Department of PathologyInstituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (INNSZ)Mexico CityMexico

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