International Journal of Colorectal Disease

, Volume 22, Issue 7, pp 727–736 | Cite as

Spontaneous regression of colorectal cancer: a review of cases from 1900 to 2005

  • Ayman S. AbdelrazeqEmail author



Spontaneous regression of cancer is an exceptional but well-documented biological event. Further understanding of this phenomenon and harnessing of the mechanisms involved will have significant preventative and therapeutic implications.


In this review, the literature of spontaneous regression of colon or rectal cancer is reviewed from 1965 to 2005 to update reviews by Everson et al., Boyd and Challis et al. By adding to these, the author reports the entire series of colorectal cancer, which underwent documented spontaneous regression from 1900 to 2005. The demographic and pathologic characteristics, the details of regression and the outcome of reported cases are presented and discussed. Special emphasis is placed on identifying possible causes hypothesized by authors for occurrence of regression. Possible mechanisms operating to affect these regressions are also discussed.


Colorectal Neoplasm Malignant Spontaneous Remission Regression 



The interest and the generous provision of the bibliography of reported cases of cancer SR from 1965 to 1987 by Dr. J.H. Stam of the Calgary University, Canada is deeply appreciated.


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© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Colorectal Unit, Department of SurgeryHuddersfield Royal InfirmaryHuddersfieldUK
  2. 2.YorkUK

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