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International Journal of Colorectal Disease

, Volume 22, Issue 7, pp 749–756 | Cite as

No prognostic impact of isolated lymphovascular invasion after radical resection of rectal cancer—results of a multicenter observational study

  • Henry PtokEmail author
  • Frank Meyer
  • Ralf Steinert
  • Michael Vieth
  • Karsten Ridwelski
  • Hans Lippert
  • Ingo Gastinger
  • Study Group “Colon/Rectum Carcinoma (Primary Tumor Lesion)”
Original Article

Abstract

Background

The prognostic impact of isolated lymphovascular invasion (LVI) after radical resection of rectal cancer is controversially discussed. However, it could be relevant to decide for an adjuvant treatment.

Aim

The aim of the analysis was, based on the data of an observational study, to determine the prognostic relevance of the isolated LVI.

Materials and methods

Patients after radical resection of rectal cancer with no hemangioinvasion were subdivided in three groups: I—no LVI, no lymph node metastases (LNM); II—positive LVI, no LNM; III—positive LNM. Five-year local recurrence rate, distant metastases-free and disease-free survival were determined uni- and multivariate.

Results

Patients, n = 846, were studied (I, n = 471; II, n = 75; III, n = 300). The univariate comparison between the groups revealed the following 5-year results: local recurrence rate: 9.4 vs 10.0 vs 14.0%; distant metastases-free survival: 84.1 vs 82.5 vs 49.3%; disease-free survival: 83.2 vs 80.7 vs 45.5%. The differences between groups I and III were significant, but not between groups I and II. The determined higher disease-free survival rate in group II vs group III was significant (P = 0.041), but the differences in local recurrence rate and rate of distant metastases did not reach statistical significance. The multivariate analysis revealed no impact of the isolated LVI on the oncological outcome.

Conclusion

The isolated LVI has no independent prognostic impact on the local recurrence rate and long-term survival after radical resection of rectal cancer. Based on this finding, no indication for an adjuvant treatment in these patients can be derived.

Keywords

Rectal cancer Lymphovascular invasion Lymph node metastasis 5-year local recurrence rate Disease-free survival 

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Henry Ptok
    • 1
    • 2
    Email author
  • Frank Meyer
    • 1
  • Ralf Steinert
    • 2
  • Michael Vieth
    • 3
  • Karsten Ridwelski
    • 4
  • Hans Lippert
    • 1
  • Ingo Gastinger
    • 2
  • Study Group “Colon/Rectum Carcinoma (Primary Tumor Lesion)”
    • 5
  1. 1.Department of General, Abdominal and Vascular SurgeryUniversity HospitalMagdeburgGermany
  2. 2.Department of SurgeryCarl-Thiem HospitalCottbusGermany
  3. 3.Institute of PathologyMunicipal HospitalBayreuthGermany
  4. 4.Department of SurgeryMunicipal HospitalMagdeburgGermany
  5. 5.Institute for Quality ControlUniversity HospitalMagdeburgGermany

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