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The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Objective

The aim of this review is to clarify the involvement of the insulinlike growth factor (IGF) system in the development of colorectal malignancy.

Materials and methods

Medline searches were used to identify key articles relating the IGF system with the development of colorectal cancer.

Results

The IGF system has been linked to colorectal malignancy by a convergence of data from epidemiological, clinical and laboratory-based sources.

Conclusion

Further work is needed to characterise the IGF system expression in the colon. Such clarification could lead to the identification of targets that can be manipulated for clinical advantage.

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Authors and Affiliations

  1. University Department of Surgery, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK

    M. Davies, S. Gupta & M. Winslet

  2. Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK

    G. Goldspink

  3. University Department of Surgery, Royal Free and University College Medical School, Pond Street, London, NW3 2QG, UK

    M. Winslet

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  1. M. Davies
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Correspondence to M. Winslet.

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Davies, M., Gupta, S., Goldspink, G. et al. The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence. Int J Colorectal Dis 21, 201–208 (2006). https://doi.org/10.1007/s00384-005-0776-8

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