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International Journal of Colorectal Disease

, Volume 21, Issue 3, pp 201–208 | Cite as

The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence

  • M. Davies
  • S. Gupta
  • G. Goldspink
  • M. WinsletEmail author
Review

Abstract

Objective

The aim of this review is to clarify the involvement of the insulinlike growth factor (IGF) system in the development of colorectal malignancy.

Materials and methods

Medline searches were used to identify key articles relating the IGF system with the development of colorectal cancer.

Results

The IGF system has been linked to colorectal malignancy by a convergence of data from epidemiological, clinical and laboratory-based sources.

Conclusion

Further work is needed to characterise the IGF system expression in the colon. Such clarification could lead to the identification of targets that can be manipulated for clinical advantage.

Keywords

Colorectal Cancer Insulinlike Growth Factor Acromegaly Insulinlike Growth Factor Receptor Acromegalic Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • M. Davies
    • 1
  • S. Gupta
    • 1
  • G. Goldspink
    • 2
  • M. Winslet
    • 1
    • 3
    Email author
  1. 1.University Department of SurgeryRoyal Free and University College Medical SchoolLondonUK
  2. 2.Department of Anatomy and Developmental BiologyRoyal Free and University College Medical SchoolLondonUK
  3. 3.University Department of SurgeryRoyal Free and University College Medical SchoolLondonUK

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