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International Journal of Colorectal Disease

, Volume 19, Issue 6, pp 533–537 | Cite as

Prognostic significance of microsatellite instability in sporadic colorectal cancer

  • Seok-Byung Lim
  • Seung-Yong Jeong
  • Min Ro Lee
  • Ja-Lok Ku
  • Young-Kyoung Shin
  • Woo Ho Kim
  • Jae-Gahb ParkEmail author
Original Article

Abstract

Background and aims

Colorectal cancers exhibiting microsatellite instability (MSI) appear to have unique biological behavior. The influence of MSI on the prognosis of sporadic colorectal cancers is controversial and requires further investigation. The aim of this study was to analyze the association between MSI status and clinicopathological features and prognosis in sporadic colorectal cancer patients.

Patients and methods

Of the 322 consecutive colorectal cancer patients operated upon at the Seoul National University Hospital between January and December 1998, we examined the clinicopathological features and prognosis of 248 patients with sporadic primary colorectal cancer. The MSI status of these 248 patients has been reported in a previous study. Of the 248 patients, 23 (9.3%) had MSI+ tumors. The patients’ clinicopathological parameters were obtained from their medical records, and follow-up and survival data were obtained from medical records and phone calls.

Results

MSI+ sporadic colorectal cancers were found predominantly in the proximal colon (p<0.001) and were associated with poor differentiation (p=0.030), a lower preoperative serum carcinoembryonic antigen (CEA) level (p=0.012), and less frequent systemic metastasis (p=0.034) than MSI− tumors. Low tumor grade (p=0.022), low tumor T-stage (p=0.002), no lymph node metastasis (p<0.001), no systemic metastasis (p<0.001), adjuvant chemotherapy (p<0.001) and MSI+ status (p=0.038) were independent favorable prognostic factors for survival in sporadic colorectal cancer patients.

Conclusion

MSI status was an independent favorable prognostic factor for survival in sporadic primary colorectal cancer patients.

Keywords

Microsatellite instability Prognosis Sporadic colorectal cancer 

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Seok-Byung Lim
    • 1
  • Seung-Yong Jeong
    • 2
    • 3
  • Min Ro Lee
    • 1
  • Ja-Lok Ku
    • 2
  • Young-Kyoung Shin
    • 2
  • Woo Ho Kim
    • 4
  • Jae-Gahb Park
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of SurgerySeoul National University College of MedicineSeoulKorea
  2. 2.Cancer Research Center and Cancer Research InstituteSeoul National UniversitySeoulKorea
  3. 3.Research Institute and HospitalNational Cancer CenterGyeonggiKorea
  4. 4.Department of PathologySeoul National University College of MedicineSeoulKorea

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