International Journal of Colorectal Disease

, Volume 19, Issue 6, pp 510–517

Vascular endothelial growth factor in colorectal cancer

  • Markus Guba
  • Hendrik Seeliger
  • Axel Kleespies
  • Karl-Walter Jauch
  • Christiane Bruns



Angiogenesis plays an important role in colorectal cancer progression. Evidence from preclinical and clinical studies indicates that vascular endothelial growth factor (VEGF) is the predominant angiogenic factor in human colorectal cancer and is associated with formation of metastases and poor prognosis. Based on these results it was hypothesized that attacking one or more of the VEGF-mediated mechanisms may be promising in the treatment of colorectal cancer.


This article reviews the role of VEGF in colon cancer and summarizes recent advances in the treatment of colorectal cancer by anti-VEGF strategies.


Anti-angiogenic therapy Clinical trials targeting VEGF Colorectal cancer Colorectal cancer metastases Prognostic value VEGF VEGF pathway 


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Markus Guba
    • 1
  • Hendrik Seeliger
    • 1
  • Axel Kleespies
    • 1
  • Karl-Walter Jauch
    • 1
  • Christiane Bruns
    • 1
  1. 1.Department of Surgery, University Clinic GrosshadernLudwig-Maximilians-UniversityMunichGermany

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