International Journal of Colorectal Disease

, Volume 19, Issue 2, pp 157–164 | Cite as

Long-term effect of 5-fluorouracil enhanced by intermittent administration of polysaccharide K after curative resection of colon cancer

A randomized controlled trial for 7-year follow-up
  • Katsuki ItoEmail author
  • Hiroaki Nakazato
  • Akihiko Koike
  • Hiroshi Takagi
  • Shigetoyo Saji
  • Shozo Baba
  • Masayoshi Mai
  • Jun-ichi Sakamoto
  • Yasuo Ohashi
Original Article


Background and aims

The efficacy of a biological response modifier polysaccharide K in adjuvant immunochemotherapy was evaluated in primary colon cancer patients with macroscopic Dukes' C after curative resection.

Patients and methods

Employing the minimization method using three factors (lymph node metastases, preoperative serum CEA level, and institution), 446 patients were allocated into groups P and C. Group P received immunochemotherapy, oral PSK (3 g per day) followed by oral 5-FU (200 mg/body per day), while group C received only intermittent chemotherapy, oral 5-FU (200 mg per day) followed by 4-week rest. Both groups received ten courses.


Survival for cancer death was significantly higher in group P than in group C, but there was no difference in 7-year disease-free survival or overall survival had.


Repeated alternating administration with PSK followed by 5-FU can improve survival for cancer death.


5-Fluorouracil Polysaccharide K Colon cancer Immunochemotherapy Intermittent administration 



We thank Ms. Atsuko Tanaka for the assistance in the preparation of the manuscript.


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Katsuki Ito
    • 1
    Email author
  • Hiroaki Nakazato
    • 2
  • Akihiko Koike
    • 3
  • Hiroshi Takagi
    • 1
  • Shigetoyo Saji
    • 4
  • Shozo Baba
    • 5
  • Masayoshi Mai
    • 6
  • Jun-ichi Sakamoto
    • 7
  • Yasuo Ohashi
    • 8
  1. 1.Department of Surgery 2Nagoya University School of MedicineNagoyaJapan
  2. 2.Yokoyama Gastrointestinal HospitalNagoyaJapan
  3. 3.Department of Surgery 1Aichi Medical UniversityAichiJapan
  4. 4.Department of Surgery 2Gifu University School of MedicineGifuJapan
  5. 5.Department of Surgery 2Hamamatsu University School of MedicineHamamatsuJapan
  6. 6.Cancer Research InstituteKanazawa UniversityKanazawaJapan
  7. 7.Department of SurgeryAichi Prefectural HospitalOkazakiJapan
  8. 8.Department of Health Science, Faculty of MedicineUniversity of TokyoTokyoJapan

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