Pediatric Surgery International

, Volume 36, Issue 3, pp 357–363 | Cite as

Treatment patterns and outcomes for pancreatic tumors in children: an analysis of the National Cancer Database

  • Omar Picado
  • Anthony Ferrantella
  • Celisse Zabalo
  • Krishnamurti Rao
  • Chad M. Thorson
  • Juan E. Sola
  • Eduardo A. PerezEmail author
Original Article



Pancreatic tumors are rare in children and limited data are available regarding incidence, treatment, and outcomes. We aim to describe patient and tumor characteristics and to report on survival of these diseases.


Children with pancreatic tumors were queried from the National Cancer Database (2004–2014). The association between treatment and hazard of death was assessed using Kaplan–Meier method and Cox regression model.


We identified 109 children with pancreatic tumors; 52% were male and median age at diagnosis was 14 years. Tumors were distributed as follows: pseudopapillary neoplasm (30%), endocrine tumors (27%), pancreatoblastoma (16%), pancreatic adenocarcinoma (16%), sarcoma (6%) and neuroblastoma (5%). Seventy-nine patients underwent surgery, of which 76% achieved R0 resection. Most patients (85%) had lymph nodes examined, of which 22% had positive nodes. Five-year overall survival by tumor histology was 95% (pseudopapillary neoplasm), 75% (neuroblastoma), 70% (pancreatoblastoma), 51% (endocrine tumors), 43% (sarcoma), and 34% (adenocarcinoma). On multivariable analysis, surgical resection was the strongest predictor of survival (HR 0.26, 95% CI 0.10–0.68, p < 0.01).


Overall survival of children with pancreatic tumors is grim, with varying survival rates among different tumors. Surgical resection is associated with improved long-term survival.


Pancreatic tumors Pediatric Children Survival Treatment 


Author contributions

OP and EAP contributed to the study conception and design and performed the data collection and analysis; OP, AF, CZ, and KR prepared the manuscript; CMT, JES, and EAP provided critical revisions to the manuscript. All authors read and approved the final manuscript.


This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest in this work.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2020

Authors and Affiliations

  • Omar Picado
    • 1
  • Anthony Ferrantella
    • 1
  • Celisse Zabalo
    • 1
  • Krishnamurti Rao
    • 1
  • Chad M. Thorson
    • 1
  • Juan E. Sola
    • 1
  • Eduardo A. Perez
    • 1
    Email author
  1. 1.Division of Pediatric Surgery, DeWitt Daughtry Family Department of SurgeryUniversity of Miami Leonard M. Miller School of MedicineMiamiUSA

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