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Urinary nerve growth factor: a biomarker for overactive bladder in children? A meta-analysis and trail sequential analysis

  • Changkai DengEmail author
  • Qiang Peng
  • Xianliang Hu
  • Li Gao
  • Juan Xu
  • Jing Su
  • Xue Xia
  • Feng Liu
  • Maoxian Li
Original Article
  • 71 Downloads

Abstract

Purpose

Based on previously two meta-analyses, urinary nerve growth factor (NGF) has emerged as one potentially noninvasive biomarker for overactive bladder (OAB) in adults. We performed this systematic review to explore if NGF is a biomarker for OAB in children.

Methods

A literature search was conducted in PubMed, Embase, Web of science and Cochrane Library. Copies of all relevant articles were retrieved for quality assessment and data abstraction by two reviewers. Primary outcome was pooled standardized mean difference (SMD) for NGF/Cr (NGF normalized to urine creatinine) level between OAB group and controls.

Results

Three case–control studies published from 2012 to 2017 were included with 99 patients and 61 controls. Children with OAB had a significant higher baseline urinary NGF/Cr level compared to controls (SMD 1.75, 95% CI 0.47–3.03, P < 0.01). After treatment, the level of NGF/Cr decreased significantly compared to baseline level at third month and sixth month time points (SMD 0.51, 95% CI = 0.14–0.88, P = 0.007 and SMD 0.68, 95% CI = 0.30–1.05, P = 0.0004). We calculated the required information size to 1306 patients for comparison of urinary NGF/Cr level between OAB and controls by trail sequential analysis (TSA).

Conclusions

Based on this systematic review, NGF/Cr may be a noninvasive biomarker for OAB in children in the future. But based on TSA, more original studies are needed to clarify the role of NGF/Cr in the biomarker effect.

Keywords

Biomarker Children Overactive bladder Systematic review Trail sequential analysis Urinary nerve growth factor 

Notes

Funding

This work was supported by Health and Family Planning Commission of Sichuan Province Research Projects (Project No. 18PJ038).

Compliance with ethical standards

Conflict of interest

The authors have no relevant financial relationships to the article to disclose.

Supplementary material

383_2019_4447_MOESM1_ESM.png (9 kb)
Supplementary Fig. S1 Forest plots of comparison of urinary NGF/Cr level between pre-treatment and post-treatment (3rd month) (PNG 9 KB)
383_2019_4447_MOESM2_ESM.png (9 kb)
Supplementary Fig. S2 Forest plots of comparison of urinary NGF/Cr level between pre-treatment and post-treatment (6th month) (PNG 9 KB)
383_2019_4447_MOESM3_ESM.png (10 kb)
Supplementary Fig. S3 Forest plots of comparison of urinary NGF/Cr level between post-treatment (3rd Month) and post-treatment (6th month) (PNG 9 KB)
383_2019_4447_MOESM4_ESM.png (8 kb)
Supplementary Fig. S4 Sensitivity analysis for comparison of urinary NGF/Cr level between OAB and controls (PNG 7 KB)
383_2019_4447_MOESM5_ESM.png (25 kb)
Supplementary Fig. S5 Sensitivity analysis for comparison of urinary NGF/Cr level between pre-treatment and post-treatment (3rd month) (PNG 25 KB)
383_2019_4447_MOESM6_ESM.png (9 kb)
Supplementary Fig. S6 Sensitivity analysis for comparison of urinary NGF/Cr level between pre-treatment and post-treatment (6th month) (PNG 9 KB)
383_2019_4447_MOESM7_ESM.png (9 kb)
Supplementary Fig. S7 Sensitivity analysis for comparison of urinary NGF/Cr level between post-treatment (3rd month) and post-treatment (6th month) (PNG 9 KB)
383_2019_4447_MOESM8_ESM.png (197 kb)
Supplementary Fig. S8 Result of TSA for comparison of urinary NGF/Cr level between OAB and controls (PNG 197 KB)
383_2019_4447_MOESM9_ESM.png (199 kb)
Supplementary Fig. S9 Result of TSA for Comparison of urinary NGF/Cr level between pre-treatment and post-treatment (3rd month) (PNG 198 KB)
383_2019_4447_MOESM10_ESM.png (205 kb)
Supplementary Fig. S10 Result of TSA for Comparison of urinary NGF/Cr level between pre-treatment and post-treatment (6th month) (PNG 204 KB)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Changkai Deng
    • 1
    Email author
  • Qiang Peng
    • 1
  • Xianliang Hu
    • 1
  • Li Gao
    • 1
  • Juan Xu
    • 1
  • Jing Su
    • 1
  • Xue Xia
    • 1
  • Feng Liu
    • 2
  • Maoxian Li
    • 1
  1. 1.Department of Pediatric SurgeryChengdu Women’s and Children’s Central Hospital of Chongqing Medical UniversityChengduChina
  2. 2.Department of Urology SurgeryChildren’s Hospital of Chongqing Medical UniversityChongqingChina

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