A periodic comparison of the survival and prognostic factors of biliary atresia after Kasai portoenterostomy: a single-center study in Korea

  • Kyong Ihn
  • Younghyun Na
  • In Geol Ho
  • Dongeun Lee
  • Hong Koh
  • Seok Joo HanEmail author
Original Article



We explored the chronologic changes in prognostic factors and clinical outcomes of Kasai portoenterostomy (KPE) for biliary atresia (BA).


Patients undergoing KPE between 1997 and 2016 were analyzed retrospectively. Ninety-two consecutive patients who underwent KPE from 1997 to 2006 (Era 1) were compared with 150 patients who underwent KPE from 2007 to 2016 (Era 2) for clinical outcomes and prognostic factors.


The jaundice clearance rate increased by 8.8% (66.7% vs. 75.5% for Eras 1 and 2, respectively, p = 0.180), and the 5-year native liver survival (NLS) rate improved slightly (62.5% vs. 64.0% for Eras 1 and 2, respectively, p = 0.617) in Era 2. The hazard ratio for age at KPE (≥ 90 days) with regard to 5-year NLS and the odds ratio for age at KPE (< 90 days) with regard to jaundice clearance were both lower in Era 2 than in Era 1 (1.95 vs. 2.25 and 2.67 vs. 5.21, respectively).


The clinical outcomes improved over a period in a single surgeon’s practice. We demonstrated that the impact of age at the time of KPE on operative outcomes became less significant over time with the increase in the single surgeon’s experience and improvement in medical treatment for BA.


Biliary atresia Kasai portoenterostomy Prognosis Liver fibrosis Native liver survival 


Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest or financial relationships relevant to this article to disclose.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the institutional review board of Severance Hospital (approval number: 4-2017-1101).

Informed consent

A waiver of informed consent was granted because the study was determined to be minimal risk and because data are de-identified.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Kyong Ihn
    • 1
  • Younghyun Na
    • 1
  • In Geol Ho
    • 1
  • Dongeun Lee
    • 1
  • Hong Koh
    • 2
  • Seok Joo Han
    • 1
    Email author
  1. 1.Department of Pediatric Surgery, Severance Pediatric Liver Disease Research Group, Severance Children’s Hospital, Department of SurgeryYonsei University College of MedicineSeoulKorea
  2. 2.Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Severance Pediatric Liver Disease Research Group, Severance Children’s HospitalYonsei University College of MedicineSeoulKorea

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