Pediatric Surgery International

, Volume 29, Issue 7, pp 735–740 | Cite as

Prenatal and postnatal features of mesenchymal hamartoma of the chest wall: case report and literature review

  • Yelda Jozaghi
  • Sherif Emil
  • Pedro Albuquerque
  • Stephanie Klam
  • Miriam Blumenkrantz
Case Report


Mesenchymal hamartoma of the chest wall is a rare, benign chondro-osseous tumor of the bone. Although it most commonly presents at birth or soon after, prenatal detection is rare. We report a case of prenatally detected mesenchymal hamartoma, and provide the rationale, details, and outcomes of our management. The literature is reviewed, with particular attention to prenatal detection and postnatal management options.


Chest Wall Excisional Biopsy Chondroblastoma Congenital Cystic Adenomatoid Malformation Chest Wall Deformity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Braatz B, Evans R, Kelman A et al (2010) Perinatal evolution of mesenchymal hamartoma of the chest wall. J Pediatr Surg 45:37–40CrossRefGoogle Scholar
  2. 2.
    Cohen MC, Drut R, Garcia C et al (1992) Mesenchymal hamartoma of the chest wall: a cooperative study with review of the literature. Pediatr Pathol 12:525–534PubMedCrossRefGoogle Scholar
  3. 3.
    Vlychou M, Athanasou NA (2008) Radiological and pathological diagnosis of paediatric bone tumours and tumour-like lesions. Pathol 40:196–216CrossRefGoogle Scholar
  4. 4.
    Ozolek JA (2009) Selective pathologies of the head and neck in children: a developmental perspective. Adv Anat Pathol 16:332–358PubMedCrossRefGoogle Scholar
  5. 5.
    Psaila J, Carachi R, Raine PAM et al (1996) Thoracic mesenchymoma of infancy. J Pediatr Surg 31:726–728PubMedCrossRefGoogle Scholar
  6. 6.
    Lisle DA, Ault DJ, Earwaker JW (2003) Mesenchymal hamartoma of the chest wall in infants: report of three cases and literature review. Australas Radiol 47:78–82PubMedCrossRefGoogle Scholar
  7. 7.
    McLeod RA, Dahlin DC (1979) Hamartoma (mesenchymoma) of the chest wall in infancy. Radiology 131:657–661PubMedGoogle Scholar
  8. 8.
    Odell JM, Benjamin DR (1986) Mesenchymal hamartoma of chest wall in infancy: natural history of two cases. Pediatr Pathol 5:135–146PubMedCrossRefGoogle Scholar
  9. 9.
    Kerrey B, Reed J (2007) A neonate with respiratory distress and a chest wall deformity. Pediatr Emerg Care 23:565–569PubMedCrossRefGoogle Scholar
  10. 10.
    Brand MT, Hatch EI, Schaller RT (1986) Surgical management of the infant with mesenchymal hamartoma of the chest wall. J Pediatr Surg 21:556–558PubMedCrossRefGoogle Scholar
  11. 11.
    Nicholson SA, Hill DA, Foster KW et al (2000) Fine-needle aspiration cytology of mesenchymal hamartoma of the chest wall. Diagn Cytopathol 22:33–38PubMedCrossRefGoogle Scholar
  12. 12.
    Oakley RH, Carty H, Cudmore RE (1985) Multiple benign mesenchymomata of the chest wall. Pediatr Radiol 15:58–60PubMedCrossRefGoogle Scholar
  13. 13.
    Jonas RE, Kimonis VE (2001) Chest wall hamartoma with Wiedemann-Beckwith syndrome: clinical report and brief review of chromosome 11p15.5-related tumors. Am J Med Genet 101:221–225PubMedCrossRefGoogle Scholar
  14. 14.
    Groom KR, Murphey MD, Howard LM et al (2002) Mesenchymal hamartoma of the chest wall: radiologic manifestations with emphasis on cross-sectional imaging and histopathologic comparison. Radiol 222:205–211CrossRefGoogle Scholar
  15. 15.
    Yeshvanth SK, Shivamurthy V, Patil C et al (2011) Mesenchymal hamartoma of the chest wall - mimicker of malignancy. J Cancer Res Therapeut 7:496–498CrossRefGoogle Scholar
  16. 16.
    Conlan AA, Hurwitz SS, Griztman MCD (1982) Giant chondromatous hamartoma of the first rib. A case report. SAMJ 62:703–704Google Scholar
  17. 17.
    Altaner S, Yoruk Y, Bilgi S et al (2006) Multifocal mesenchymal hamartoma of the chest wall. Respirol 11:334–338CrossRefGoogle Scholar
  18. 18.
    Brar MK, Cubberley DA, Baty BJ et al (1988) Chest wall hamartoma in a fetus. J Ultrasound Med 7:217–220PubMedGoogle Scholar
  19. 19.
    D’Ercole C, Boubli L, Potier A et al (1994) Fetal chest wall hamartoma: a case report. Fet Diagn Ther 9:261–263CrossRefGoogle Scholar
  20. 20.
    Jung AL, Johnson DG, Condon VR et al (1994) Congenital chest wall mesenchymal hamartoma. J Perinatol 14:487–491PubMedGoogle Scholar
  21. 21.
    Masuzaki H, Masuzaki M, Ishimaru T et al (1996) Chest wall hamartoma diagnosed prenatally using ultrasonography and computed tomography. J Clin Ultrasound 24:83–85PubMedCrossRefGoogle Scholar
  22. 22.
    Rose NC, Coleman BG, Wallace D et al (1996) Prenatal diagnosis of a chest wall hamartoma and sternal cleft. Ultrasound Obstet Gynecol 7:453–455PubMedCrossRefGoogle Scholar
  23. 23.
    Shimotake T, Fumino S, Aoi S et al (2005) Respiratory insufficiency in a newborn with mesenchymal hamartoma of the chest wall occupying the thoracic cavity. J Pediatr Surg 40:13–16CrossRefGoogle Scholar
  24. 24.
    Odaka A, Takahashi S, Tanimizu T et al (2005) Chest wall mesenchymal hamartoma associated with a massive fetal pleural effusion: a case report. J Pediatr Surg 40:5–7CrossRefGoogle Scholar
  25. 25.
    Chu L, Seed M, Howse E et al (2011) Mesenchymal hamartoma: prenatal diagnosis by MRI. Pediatr Radiol 41:781–784PubMedCrossRefGoogle Scholar
  26. 26.
    Sodhi KS, Aiyappan SK, Menon P et al (2009) Unilateral multifocal mesenchymal hamartoma of the chest wall: a case report and review of literature. J Pediatr Surg 44:464–467PubMedCrossRefGoogle Scholar
  27. 27.
    DeRosa GP (1985) Progressive scoliosis following chest wall resection in children. Spine 10:618–622PubMedCrossRefGoogle Scholar
  28. 28.
    Dounies R, Chwals WJ, Lally KP et al (1994) Hamartomas of the chest wall in infants. Ann Thorac Surg 57:868–875PubMedCrossRefGoogle Scholar
  29. 29.
    Ayala AG, Ro JY, Bolio-Solis A et al (1993) Mesenchymal hamartoma of the chest wall in infants and children: a clinicopathological study of five patients. Skeletal Radiol 22:569–576PubMedCrossRefGoogle Scholar
  30. 30.
    Blumenthal BI, Capitanio MA, Queloz JM et al (1972) Intrathoracic mesenchymoma: observations in two infants. Radiology 104:107–109PubMedGoogle Scholar
  31. 31.
    Cameron D, Ong TH, Borzi P (2001) Conservative management of mesenchymal hamartomas of the chest wall. J Pediatr Surg 36:1346–1349PubMedCrossRefGoogle Scholar
  32. 32.
    Freeburn AM, McAloon J (2001) Infantile chest hamartoma—case outcome aged 11. Arch Dis Child 85:244–245PubMedCrossRefGoogle Scholar
  33. 33.
    Tsuji Y, Maeda K, Tazuke Y et al (2012) Mesenchymal hamartoma of the bilateral chest wall in neonates. Pediatr Surg Int 28:939–942PubMedCrossRefGoogle Scholar
  34. 34.
    Li R, Kelly D, Siegal GP (2012) Bilateral mesenchymal hamartoma of the chest wall in an infant boy. Fet Pediatr Pathol 31:415–422CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Yelda Jozaghi
    • 1
  • Sherif Emil
    • 2
  • Pedro Albuquerque
    • 1
  • Stephanie Klam
    • 3
  • Miriam Blumenkrantz
    • 4
  1. 1.Division of Pediatric RadiologyMcGill University Faculty of MedicineMontrealCanada
  2. 2.Division of Pediatric General and Thoracic SurgeryMontreal Children’s Hospital, McGill University Health CentreMontrealCanada
  3. 3.Department of Obstetrics and Gynecology, Jewish General HospitalMcGill University Faculty of MedicineMontrealCanada
  4. 4.Division of Pediatric PathologyMcGill University Faculty of MedicineMontrealCanada

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