Pediatric Surgery International

, Volume 28, Issue 12, pp 1171–1175

A morphological study of the removed livers from patients receiving living donor liver transplantation for adult biliary atresia

  • Toshiharu Matsuura
  • Kenichi Kohashi
  • Yusuke Yanagi
  • Isamu Saeki
  • Makoto Hayashida
  • Shinichi Aishima
  • Yoshinao Oda
  • Tomoaki Taguchi
Original Article

DOI: 10.1007/s00383-012-3183-6

Cite this article as:
Matsuura, T., Kohashi, K., Yanagi, Y. et al. Pediatr Surg Int (2012) 28: 1171. doi:10.1007/s00383-012-3183-6

Abstract

Background

In liver transplantation (LT) for adult biliary atresia (BA), we often encounter a cirrhotic deformation of the native liver. We aimed to investigate a morphological study of the removed livers and the patient’s clinical status.

Methods

We examined 8 BA patients who had undergone LT in adulthood at our hospital. The presence of hypertrophic or atrophic areas of the removed liver was recorded macroscopically. We graded the microscopic findings in the porta hepatis area, a hypertrophic area, and an atrophic area, respectively. Moreover, we investigated the relationship between these morphological findings and the pre-transplant clinical status (MELD score).

Results

Macroscopically, a hypertrophic area existed in central liver in all cases (8/8 cases), while an atrophic area was existed in peripheral liver (7/8 cases). Microscopically, an atrophic area was the most severely impaired, while the porta hepatis and hypertrophic area were relatively intact. The pathological score in a compensatory hypertrophic area was strongly correlated with the MELD score.

Conclusions

This study suggests that the partial shrinking is not uncommon in BA cirrhotic liver. It may be due to the imbalance of bile drainage by the different segment. The patient’s pre-transplant status depends on the compensatory hypertrophic liver.

Keywords

Biliary atresia Removed liver Hypertrophy Atrophy MELD score 

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Toshiharu Matsuura
    • 1
  • Kenichi Kohashi
    • 1
    • 2
  • Yusuke Yanagi
    • 1
  • Isamu Saeki
    • 1
  • Makoto Hayashida
    • 1
  • Shinichi Aishima
    • 2
  • Yoshinao Oda
    • 2
  • Tomoaki Taguchi
    • 1
  1. 1.Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  2. 2.Department of Anatomic Pathology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

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