Pediatric Surgery International

, Volume 28, Issue 7, pp 737–740

A novel t(3;8)(p13;q21.1) translocation in a case of lipoblastoma

  • Adam S. Brinkman
  • Bradley Maxfield
  • Kara Gill
  • Neha J. Patel
  • Ankush Gosain
Case Report

Abstract

Lipoblastoma is a rare benign neoplasm of embryonic white fatty tissue primarily found in the extremities of children <3 years old (Batanian et al., Cancer Genet Cytogenet 125(1):10–13, 2001; McVay MR et al., J Pediatr Surg 41(6):1067–1071, 2006; Kamal et al., J Pediatr Surg 46(7):E9–E12, 2011). Translocations affecting the 8q11–13 region are commonly reported with lipoblastoma and proper diagnosis requires cytogenetic analysis to distinguish it from malignant myxoid liposarcoma (Miller et al., J Pediatr Surg 32(12):1771–1772, 1997; Morerio et al., Pediatr Blood Cancer 52(1):132–134, 2009). We describe an additional case of lipoblastoma containing a new translocation t(3;8)(p13;q21.1), which has not previously been reported in a healthy asymptomatic child.

Keywords

Lipoblastoma Translocation Chromosome 8 PLAG1 t(3;8)(p13;q21.1) 

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Adam S. Brinkman
    • 1
  • Bradley Maxfield
    • 2
  • Kara Gill
    • 2
  • Neha J. Patel
    • 3
  • Ankush Gosain
    • 1
  1. 1.Section of Pediatric Surgery, Department of Surgery, K4/752 Clinical Science CenterUniversity of WisconsinMadisonUSA
  2. 2.Department of Pediatric RadiologyUniversity of WisconsinMadisonUSA
  3. 3.Department of Pediatric Hematology and OncologyUniversity of WisconsinMadisonUSA

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