Intrathyroidal parathyroid carcinoma in a pediatric patient
- 120 Downloads
- 6 Citations
Abstract
Parathyroid carcinoma is unusual and its intrathyroidal variant is extremely rare. Therefore, few cases have been reported to describe a case of parathyroid carcinoma located inside the thyroid gland. The case corresponds to a 14-year-old girl who came to the office with a severe osteoarticular disease, depression, calcemia of 14.3 mg/dl and parathyroid hormone of 2,792 pg/ml. Right neck exploration was conducted and a parathyroid carcinoma was found located intrathyroidally. A right thyroid lobectomy was performed. A 20-month follow-up period revealed no recurrence of clinical or biochemical signs. In patients with severe hypercalcemia and significant elevation of parathyroid hormone, the diagnosis of parathyroid carcinoma has to be considered. It is worth highlighting the early age of presentation in this case. Treatment has allowed the effective control of the disease and its recommended long-term follow-up.
Keywords
Parathyroid cancer Thyroid neoplasm Pediatric patient Case reportReferences
- 1.Wynne AG, van Heerden J, Carney JA, Fitzpatrick LA (1992) Parathyroid carcinoma: clinical and pathologic features in 43 patients. Medicine (Baltimore) 71(4):197–205Google Scholar
- 2.De Quervain VF (1909) Parastruma maligna aberrata. Deut Zschr Chir 100:334–352CrossRefGoogle Scholar
- 3.Armstrong HG (1938) Primary carcinoma of the parathyroid with report of a case. Bull Acad M Toronto 11:105–110Google Scholar
- 4.Kirstein LJ, Ghosh BC (2001) Intrathyroid parathyroid carcinoma. J Surg Oncol 77(2):136–138PubMedCrossRefGoogle Scholar
- 5.Crescenzo DG, Shabahang M, Garvin D, Evans SR (1998) Intrathyroidal parathyroid cancer presenting as a left neck mass. Thyroid 8(7):597–599PubMedCrossRefGoogle Scholar
- 6.Schmidt JL, Perry RC, Philippsen LP, Wu HH (2002) Intrathyroidal parathyroid carcinoma presenting with only hypercalcemia. Otolaryngol Head Neck Surg 127(4):352–353PubMedCrossRefGoogle Scholar
- 7.Hussein WI, El-Maghraby TA, Al-Sanea O (2006) Hyperfunctioning intrathyroidal parathyroid carcinoma. Saudi Med J 27(8):447–450Google Scholar
- 8.Busaidy NL, Jimenez C, Habra MA, Schultz PN, El-Naggar AK, Clayman GL, Asper JA, Diaz EM Jr, Evans DB, Gagel RF, Garden A, Hoff AO, Lee JE, Morrison WH, Rosenthal DI, Sherman SI, Sturgis EM, Waguespack SG, Weber RS, Wirfel K, Vassilopoulou-Sellin R (2004) Parathyroid carcinoma: a 22-year experience. Head Neck 26(8):716–726PubMedCrossRefGoogle Scholar
- 9.Beus KS, Stack BC Jr (2004) Parathyroid carcinoma. Otolaryngol Clin North Am 37:845–854PubMedCrossRefGoogle Scholar
- 10.Shane E (2001) Clinical review 122: parathyroid carcinoma. J Clin Endocrinol Metab 86:485–493PubMedCrossRefGoogle Scholar
- 11.Rawat N, Khetan N, Williams DW, Baxter JN (2005) Parathyroid carcinoma. British J Surg 92:1345–1353CrossRefGoogle Scholar
- 12.Cryns VL, Thor A, Xu H et al (1994) Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma. N Engl J Med 330:757–761PubMedCrossRefGoogle Scholar
- 13.Wassif WS, Minoz CF, Friedman E, Wong S, Weber G, Nordenskjold M et al (1993) Familial isolated hyperparathyroidism: a distinct genetic entity with an increased risk of parathyroid cancer. J Clin Endocrinol Metab 77:1485–1489PubMedCrossRefGoogle Scholar
- 14.Lang B, Lo CY (2006) Parathyroid cancer. Surg Oncol Clin N Am 15(3):573–584PubMedCrossRefGoogle Scholar
- 15.Giessler GA, Beech DJ (2001) Nonfunctional parathyroid carcinoma. J Natl Med Assoc 93:251–255PubMedGoogle Scholar
- 16.Babar-Craig H, Quaglia A, Stearns M (2005) Parathyroid carcinoma: a report of two cases and a concise review and update of the literature. J Laryngol Otol 119(7):577–580PubMedCrossRefGoogle Scholar
- 17.Schantz A, Castleman B (1973) Parathyroid carcinoma. A study of 70 cases. Cancer 31(3):600–605PubMedCrossRefGoogle Scholar
- 18.Bondeson L, Sandelin K, Grimelius L (1993) Histological variables and DNA cytometry in parathyroid carcinoma. Am J Surg Pathol 17:820–829PubMedCrossRefGoogle Scholar
- 19.Rodan GA (2002) Bisphosphonates and primary hyperparathyroidism. J Bone Miner Res 17(Suppl 2):150–153Google Scholar
- 20.Barman Balfour JA, Scott LJ (2005) Cinacalcet hydrochloride. Drugs 65(2):271–281PubMedCrossRefGoogle Scholar
- 21.Montenegro FL, Tavares MR, Durazzo MD, Cernea CR, Cordeiro AC, Ferraz AR (2006) Clinical suspicion and parathyroid carcinoma management. Sao Paulo Med J 124(1):42–44PubMedCrossRefGoogle Scholar
- 22.Thompson SD, Prichard AJN (2004) The management of parathyroid carcinoma. Curr Opin Otolaryngol Head Neck Surg 12:93–97PubMedCrossRefGoogle Scholar
- 23.Spinelli C, Bonadio AG, Berti P, Materazzi G, Miccoli P (2000) Cutaneous spreading of parathyroid carcinoma after fine needle aspiration cytology. J Endocrinol Invest 23:255–257PubMedGoogle Scholar
- 24.Moley JF, Lairmore TC, Doherty GM, Brunt LM, DeBenedetti MK (1999) Preservation of the recurrent laryngeal nerves in thyroid and parathyroid reoperations. Surgery 126(4):673–677PubMedCrossRefGoogle Scholar
- 25.Kebebew E, Arici C, Duh QY, Clark OH (2001) Localization and reoperation results for persistent and recurrent parathyroid carcinoma. Arch Surg 136(8):878–885PubMedCrossRefGoogle Scholar
- 26.Brunt L, Sicard GA (1999) Surgical Therapy of parathyroid tumors. In: Thawley S, Panje W (eds) Comprehensive management of head and neck tumors, Second edition edn. W.B. Saunders, Philadelphia, p 1795Google Scholar
- 27.Sandelin K, Auer G, Bondeson L, Grimelius L, Farnebo LO (1992) Prognostic factors in parathyroid cancer: a review of 95 cases. World J Surg 16(4):724–731PubMedCrossRefGoogle Scholar
- 28.Brassier AR, Nussbaum SR (1988) Hungry Bone Syndrome: clinical and biochemical predictors of its occurrence after parathyroid surgery. Am J Med 84:654–660CrossRefGoogle Scholar
- 29.Iacobone M, Lumachi F, Favia G (2004) Up-to-date on parathyroid carcinoma: analysis of an experience of 19 cases. J Surg Oncol 88(4):223–228PubMedCrossRefGoogle Scholar
- 30.Shaha AR, Ferlito A, Rinaldo A (2001) Distant metastases from thyroid and parathyroid cancer. ORL J Otorhinolaryngol Relat Spec 63(4):243–249PubMedCrossRefGoogle Scholar
- 31.Hundhal S, Fleming I, Fregmen A, Menck H (1999) Two hundred eighty- six cases of parathyroid carcinoma treated in the US between 1985 and 1995. A national cancer data base report. Cancer 86:538–544CrossRefGoogle Scholar