Pediatric Surgery International

, Volume 27, Issue 7, pp 721–726 | Cite as

Chinese pediatric and adolescent primary tracheobronchial tumors: a hospital-based study

  • Yongfeng Yu
  • Zhengbo Song
  • Zhiwei Chen
  • Hong Jian
  • Shun Lu
Original Article

Abstract

Objectives

To investigate the clinical characteristics and treatment outcomes in Chinese pediatric and adolescent patients with primary tracheobronchial tumors by focusing upon the exploration of prognostic factors.

Methods

A retrospective review of medical records collected from January 1996 through June 2009 was conducted within a single institution, inclusive of the total 19 treated pediatric and adolescent patients (3 benign tumors, 16 malignant tumors). A parallel comparison of adult cases with tracheobronchial tumor was performed to the pediatric and adolescent cases.

Results

The chart review of pediatric and adolescent case reports revealed 19 cases with primary tracheobronchial tumors. Final pathologic diagnosis included 14 (73.68%) mucoepidermoid carcinoma (ME), 2 (10.53%) carcinoid tumor, 2 (10.53%) papillomatosis and 1 (5.26%) neurofibroma. Median age upon diagnosis was 12 years (range 4–18 years). Chest imaging revealed common abnormal radiographic atelectasis (12/19). Patients with localized disease received surgical tumor resection. There were a total of 8 (42.1%) sleeve resections, 4 (21.1%) resection of anatomically related lung parenchyma (1 bilateral lobectomies, 2 lobectomies, 1 pneumonectomy) and 7 local tumor resections. No surgery-related deaths or complications were observed. 16 patients (84.2%) remained disease free with a median follow-up of 70.5 months (range 44–168 months).

Conclusions

Our hospital data indicated a high incidence of ME, presenting the difference in the incidence rates between Chinese and western populations. Sleeve lobectomy provides efficient treatment with excellent prognosis among Chinese pediatric and adolescent patients.

Keywords

Children Tracheobronchial tumor Mucoepidermoid carcinoma Carcinoid tumor 

Notes

Conflict of interest

The authors declare no conflicts of interest.

References

  1. 1.
    Al-Qahtani AR, Di Lorenzo M, Yazbeck S (2003) Endobronchial tumors in children: institutional experience and literature review. J Pediatr Surg 38:733–736PubMedCrossRefGoogle Scholar
  2. 2.
    Hartman GE, Shochat SJ (1983) Primary pulmonary neoplasms of childhood: a review. Ann Thorac Surg 36:108–119PubMedCrossRefGoogle Scholar
  3. 3.
    Curtis JM, Lacey D, Smyth R, Carty H (1998) Endobronchial tumours in childhood. Eur J Radiol 29:11–20PubMedCrossRefGoogle Scholar
  4. 4.
    Neville HL, Hogan AR, Zhuge Y, Perez EA, Cheung MC, Koniaris LG, Thompson WR, Sola JE (2009) Incidence and outcomes of malignant pediatric lung neoplasms. J Surg Res 156:224–230PubMedCrossRefGoogle Scholar
  5. 5.
    Hancock BJ, Di Lorenzo M, Youssef S, Yazbeck S, Marcotte JE, Collin PP (1993) Childhood primary pulmonary neoplasms. J Pediatr Surg 28:1133–1136PubMedCrossRefGoogle Scholar
  6. 6.
    de Jong WK, Schaapveld M, Blaauwgeers JL, Groen HJ (2008) Pulmonary tumours in the Netherlands: focus on temporal trends in histology and stage and on rare tumors. Thorax 63:1096–1102PubMedCrossRefGoogle Scholar
  7. 7.
    Granata C, Battistini E, Toma P, Balducci T, Mattioli G, Fregonese B, Gambini C, Rossi GA (1997) Mucoepidermoid Carcinoma of the bronchus: a case report and review of the literature. Pediatr Pulmonol 23:226–232PubMedCrossRefGoogle Scholar
  8. 8.
    Tsuchiya H, Nagashima K, Ohashi S, Takase Y (1997) Childhood bronchial mucoepidermoid tumors. J Pediatr Surg 32:106–109PubMedCrossRefGoogle Scholar
  9. 9.
    Wang LT, Wilkins EW Jr, Bode HH (1993) Bronchial carcinoid tumors in pediatric patients. Chest 103:1426–1428PubMedCrossRefGoogle Scholar
  10. 10.
    Ishizumi T, Tateishi U, Watanabe S, Maeda T, Arai Y (2007) F-18 FDG PET/CT imaging of low-grade mucoepidermoid carcinoma of the bronchus. Ann Nucl Med 21:299–302PubMedCrossRefGoogle Scholar
  11. 11.
    Marom EM, Sarvis S, Herndon JE 2nd, Patz EF Jr (2002) T1 lung cancers: sensitivity of diagnosis with fluorodeoxyglucose PET. Radiology 223:453–459PubMedCrossRefGoogle Scholar
  12. 12.
    Jadvar H, Segall GM (1997) False-negative fluorine-18-FDG PET in metastatic carcinoid. J Nucl Med 38:1382–1383PubMedGoogle Scholar
  13. 13.
    Gaissert HA, Mathisen DJ, Grillo HC, Vacanti JP, Wain JC (1994) Tracheobronchial sleeve resection in children and adolescents. J Pediatr Surg 29:192–198PubMedCrossRefGoogle Scholar
  14. 14.
    Hanagiri T, Baba T, Ichiki Y, Yasuda M, Sugaya M, Ono K, Uramoto H, Takenoyama M, Yasumoto K (2010) Sleeve lobectomy for patients with non-small cell lung cancer. Int J Surg 8:39–43PubMedCrossRefGoogle Scholar
  15. 15.
    Rizzardi G, Marulli G, Bortolotti L, Calabrese F, Sartori F, Rea F (2008) Sleeve resections and bronchoplastic procedures in typical central carcinoid tumors. Thorac Cardiovasc Surg 56:42–45PubMedCrossRefGoogle Scholar
  16. 16.
    Rizzardi G, Marulli G, Calabrese F, Rugge M, Rebusso A, Sartori F, Rea F (2009) Bronchial carcinoid tumours in children: surgical treatment and outcome in a single institution. Eur J Pediatr Surg 19:228–231PubMedCrossRefGoogle Scholar
  17. 17.
    Díaz Jiménez JP, Canela Cardona M, Maestre Alcacer J, Balust Vidal M, Fontanals Tortra J, Balust Vidal J (1989) Treatment of obstructive tracheobronchial disease with the Yag-Nd laser: 400 procedures in a 4-year experience. Med Clin (Barc) 93:244–248Google Scholar
  18. 18.
    Kvernebo K, Lunde OC, Clausen T, Kollerøs D, Myklebust R, Hansen G, Røtnes T (1991) Tracheobronchial tumors treated with laser.7-year experiences at Aker hospital. Tidsskr Nor Laegeforen 111:2744–2746PubMedGoogle Scholar
  19. 19.
    Han SW, Kim HP, Jeon YK, Oh DY, Lee SH, Kim DW, Im SA, Chung DH, Heo DS, Bang YJ, Kim TY (2008) Mucoepidermoid carcinoma of lung: potential target of EGFR-directed treatment. Lung Cancer 61:30–34PubMedCrossRefGoogle Scholar
  20. 20.
    Oskarsson T, Jonsson OG, Kristinsson JR, Jonmundsson GK, Jonasson JG, Haraldsson A (2010) Childhood cancer in Iceland 1981–2006. Laeknabladid 96:21–26PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Yongfeng Yu
    • 1
  • Zhengbo Song
    • 1
  • Zhiwei Chen
    • 1
  • Hong Jian
    • 1
  • Shun Lu
    • 1
  1. 1.Shanghai Lung Tumor Clinical CenterChest Hospital affiliated to Shanghai Jiaotong UniversityShanghaiChina

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