Pediatric Surgery International

, Volume 27, Issue 1, pp 1–8 | Cite as

Outcome of hepatoblastomas treated using the Japanese Study Group for Pediatric Liver Tumor (JPLT) protocol-2: report from the JPLT

  • Tomoro Hishiki
  • Tadashi Matsunaga
  • Fumiaki Sasaki
  • Michihiro Yano
  • Kohmei Ida
  • Hiroshi Horie
  • Satoshi Kondo
  • Ken-Ichiro Watanabe
  • Takaharu Oue
  • Tatsuro Tajiri
  • Arata Kamimatsuse
  • Naomi Ohnuma
  • Eiso Hiyama
Original Article



In the recent years, surgical resection with pre- and/or postoperative chemotherapy has markedly improved the survival rate of hepatoblastoma patients. We herein report the results of patients treated with the current protocol of the Japanese Study Group for Pediatric Liver Tumor, JPLT-2.


A total of 279 patients with malignant liver tumor were enrolled in JPLT-2. Data from 212 hepatoblastoma cases were analyzed. PRETEXT I patients were treated with primary resection followed by low doses of cisplatin–pirarubicin (tetrahydropyranyl-adriamycin). Otherwise, patients received preoperative cisplatin–pirarubicin (CITA), followed by surgery and postoperative chemotherapy. Ifosfamide, pirarubicin, etoposide, and carboplatin (ITEC) were given as a salvage treatment. High-dose chemotherapy with hematopoietic stem cell transplantation (SCT) was reserved for patients with metastatic diseases.


The 5-year overall survival rate (OS) in non-metastatic cases was 100% for PRETEXT I, 87.1% for PRETEXT II, 89.7% for PRETEXT III, and 78.3% for PRETEXT IV. The 5-year OS in metastatic cases was 43.9%. The outcome in non-metastatic PRETEXT IV cases was markedly improved, while the results of metastatic tumors remained poor.


JPLT-2 protocol achieved satisfactory survival among children with non-metastatic hepatoblastoma. New approaches are needed for patients with metastatic diseases.


Hepatoblastoma Prognostic factors PRETEXT Survival 



We would like to thank all the staff at institutes that participated in JPLT for enrolling their patients into the study. We also thank the following previous core members of JPLT, who participated in designing the initial JPLT-2 protocol in 1998; Drs. Yutaka Hayashi, Akira Hayashi, Kohei Hashizume, Hideo Mugishima.

Conflict of interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Tomoro Hishiki
    • 1
  • Tadashi Matsunaga
    • 1
  • Fumiaki Sasaki
    • 2
  • Michihiro Yano
    • 3
  • Kohmei Ida
    • 4
  • Hiroshi Horie
    • 5
  • Satoshi Kondo
    • 6
  • Ken-Ichiro Watanabe
    • 7
  • Takaharu Oue
    • 8
  • Tatsuro Tajiri
    • 9
  • Arata Kamimatsuse
    • 10
  • Naomi Ohnuma
    • 1
  • Eiso Hiyama
    • 10
  1. 1.Department of Pediatric SurgeryChiba University Graduate School of MedicineChibaJapan
  2. 2.Department of Pediatric SurgeryHokkaido University Graduate School of MedicineSapporoJapan
  3. 3.Department of PediatricsAkita University School of MedicineAkitaJapan
  4. 4.Department of Pediatrics, Graduate School of MedicineUniversity of TokyoTokyoJapan
  5. 5.Division of PathologyChiba Children’s HospitalChibaJapan
  6. 6.Division of Pediatric Surgery and Transplant SurgeryNagoya City University Medical SchoolNagoyaJapan
  7. 7.Department of Pediatrics, Graduate School of MedicineKyoto UniversityKyotoJapan
  8. 8.Division of Pediatric Surgery, Department of SurgeryOsaka University Graduate School of MedicineOsakaJapan
  9. 9.Department of Pediatric Surgery, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  10. 10.Department of Pediatric Surgery, Graduate School of Biomedical ScienceHiroshima UniversityHiroshimaJapan

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