Pediatric Surgery International

, Volume 22, Issue 12, pp 945–959 | Cite as

Enteric nervous system and developmental abnormalities in childhood

  • Thambipillai Sri Paran
  • Udo Rolle
  • Prem PuriEmail author
Review Article


ENS consists of a complex network of neurons, organised in several plexuses, which interact by means of numerous neurotransmitters. It is capable of modulating the intestinal motility, exocrine and endocrine secretions, microcirculation and immune and inflammatory responses within the gastrointestinal tract, independent of the central nervous system. Though the embryological development of various plexuses are completed by mid-way of gestation, the maturation of neurons and nerve plexuses appear to continue well after birth. Therefore, any histological or functional abnormalities related to the gastrointestinal function must be investigated with the ongoing maturational processes in mind.


Neural Crest Cell Enteric Nervous System Myenteric Plexus Chronic Constipation Enteric Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Thambipillai Sri Paran
    • 1
  • Udo Rolle
    • 1
    • 2
  • Prem Puri
    • 1
    Email author
  1. 1.Children’s Research Centre, Our Lady’s Children’s HospitalUniversity College DublinDublin 12Ireland
  2. 2.Department of Paediatric SurgeryUniversity of LeipzigLeipzigGermany

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