Pediatric Surgery International

, Volume 21, Issue 10, pp 839–840 | Cite as

Colorectal cancer with neuroendocrine differentiation in a child

  • Carlo Angelini
  • Stefano Crippa
  • Fabio Uggeri
  • Claudia Bonardi
  • Paola Sartori
  • Franco Uggeri
Case Report

Abstract

Colorectal cancer is extremely rare in children and presents with a poor prognosis because of the delay in diagnosis and lack of histological differentiation. We report a case of a sigmoid colon carcinoma with areas of neuroendocrine cells in a 12-year-old patient without familial occurrence of colorectal cancer. Symptoms at presentation were anaemia, anorexia, abdominal pain and weight loss. The patient was treated with radical resection and adjuvant chemotherapy. One year later, a local recurrence and hepatic metastases were diagnosed and she underwent chemotherapy and surgical resection. Twenty-six months from initial diagnosis she is alive with evidence of disease. The clinical presentation, diagnosis and treatment of the previously reported cases of colorectal cancer in children are also reviewed.

Keywords

Colorectal carcinoma Neuroendocrine neoplasm Paediatric tumours 

References

  1. 1.
    Rao BN, Pratt CB, Fleming ID, Dilawari RA, Green AA, Austin BA (1985) Colon carcinoma in children and adolescents. A review of 30 cases. Cancer 55:1322–1326PubMedCrossRefGoogle Scholar
  2. 2.
    Pratt CB, Rivera G, Shanks E, Johnson WW, Howarth C, Terrell W, Kumar AP (1977) Colorectal carcinoma in adolescents implications regarding etiology. Cancer 40:2464–2472PubMedCrossRefGoogle Scholar
  3. 3.
    Karnak I, Ciftei AO, Senocak ME, Buyukpamukcu N (1999) Colorectal carcinoma in children. J Pediatr Surg 34:1499–1454CrossRefPubMedGoogle Scholar
  4. 4.
    Andersson A, Bergdahl L (1976) Carcinoma of the colon in children: a report of six new cases and review of the literature. J Pediatr Surg 11:967–971PubMedCrossRefGoogle Scholar
  5. 5.
    Syversen U, Halvorsen T, Marvik R, Waldum HL (1995) Neuroendocrine differentiation in colorectal carcinomas. Eur J Gastroent Hepat 7:667–674Google Scholar
  6. 6.
    Bernick PE, Klimstra DS, Shia J, Minsky B, Saltz L, Shi W, Thaler H, Guillem J, Paty P, Cohen AM, Wong WD (2004) Neuroendocrine carcinomas of the colon and rectum. Dis Colon Rectum 47:163–169CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Carlo Angelini
    • 1
  • Stefano Crippa
    • 1
    • 2
  • Fabio Uggeri
    • 1
  • Claudia Bonardi
    • 1
  • Paola Sartori
    • 1
  • Franco Uggeri
    • 1
  1. 1.Department of SurgeryUniversity of Milan-Bicocca, San Gerardo HospitalMonzaItaly
  2. 2. VimercateItaly

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