Pediatric Surgery International

, Volume 21, Issue 10, pp 809–812

Lipoblastoma/lipoblastomatosis: a clinicopathologic study of 16 cases in Taiwan

  • Shih-Ming Jung
  • Pei-Yeh Chang
  • Chih-Cheng Luo
  • Chen-Sheng Huang
  • Jin-Yao Lai
  • Chuen Hsueh
Original article


Lipoblastoma/lipoblastomatosis is an uncommon benign lipomatous tumor affecting mainly infants and children. It presents as a painless mass located frequently in upper and lower extremities. The present study was conducted to characterize the clinicopathologic features of lipoblastoma/lipoblastomatosis in a Chinese population. A retrospective survey of 16 cases of pathologically confirmed lipoblastoma/lipoblastomatosis from 1988 to 2002 was performed. The available clinical information and histological sections were reviewed. The study involved 10 males and 6 females ranging in age from 5 to 49 months (median, 11.5 months). The patients presented with mass involving neck (n=5), inguina (n=3), feet (n=2), arm (n=1), leg (n=1), thorax (n=1), mesentery (n=1), buttock (n=1), and presacral region(n=1). The lesions were removed surgically. Histologically, the majority (11/16) of primary tumors were of diffuse type. Follow-up ranging from 5 to 125 months was available in 13 patients. Four patients experienced a recurrence of tumors in the neck (n=2) and lower extremities (n=2) 11–84 months after operation. The most common site of involvement of lipoblastoma/lipoblastomatosis in our series was the neck. A follow-up period of more than 3 years is recommended for patients with this condition.


Lipoblastoma Lipoblastomatosis Adipose tumor 


  1. 1.
    Weiss SW, Goldblum JR (2001) Enzinger and Weiss’s soft tissue tumors, 4th edn. Mosby, St LouisGoogle Scholar
  2. 2.
    Fletcher CDM, Unni KK, Mertens F (2002) Pathology and genetics of tumours of soft tissue and bone. IARC Press, LyonGoogle Scholar
  3. 3.
    Jaffe RH (1926) Recurrent lipomatous tumors of the groin: liposarcoma and lipoma pseudomyxomatodes. Arch Pathol 1:381–387Google Scholar
  4. 4.
    Vellios F, Baez J, Shumaker HB (1958) Lipomatosis: a tumor of fetal fat different from hibernoma. Report of a case with observations of the embryogenesis of human adipose tissue. Am J Pathol 34:1149–1159PubMedGoogle Scholar
  5. 5.
    Chung EB, Enzinger FM (1973) Benign lipoblastomatosis. An analysis of 35 cases. Cancer 32:482–492PubMedCrossRefGoogle Scholar
  6. 6.
    Stringel G, Shandling B, Mancer K (1982) Lipoblastoma in infants and children. J Pediatr Surg 17:277–280PubMedCrossRefGoogle Scholar
  7. 7.
    Arda IS, Senocak ME, Gogus S, Buyukpamukcu N (1993) A case of benign intrascrotal lipoblastoma clinically mimicking testicular torsion and review of the literature. J Pediatr Surg 28:259–261PubMedCrossRefGoogle Scholar
  8. 8.
    Collins MH, Chatten J (1997) Lipoblastoma/lipoblastomatosis: a clinicopathologic study of 25 tumors. Am J of Surg Pathol 21:1131–1137CrossRefGoogle Scholar
  9. 9.
    Rasmussen LS, Kirkegaard J, Kaasbol M (1997) Intermittent airway obstruction in a child caused by a cervical lipoblastoma. Acta Anaesthesiol Scand 41:945–946PubMedCrossRefGoogle Scholar
  10. 10.
    Farrugia MK, Fearne C (1998) Benign lipoblastoma arising in the neck. Pediatr Surg Int 13:213–214CrossRefPubMedGoogle Scholar
  11. 11.
    Ratan SK, Gambhir A, Mullick S, Ratan J (2000) Lipoblastoma of the neck. Indian J Pediatr 67:301–303PubMedCrossRefGoogle Scholar
  12. 12.
    Dilley AV, Patel DL, Hicks MJ, Brandt ML (2001) Lipoblastoma: pathophysiology and surgical management. J Pediatr Surg 36:229–231CrossRefPubMedGoogle Scholar
  13. 13.
    Chun YS, Kim WK, Park KW, Lee SC, Jung SE (2001) Lipoblastoma. J Pediatr Surg 36:905–907CrossRefPubMedGoogle Scholar
  14. 14.
    Basaran UN, Inan M, Bilgi S, Pul M (2001) Lipoblastoma: a rare cervical mass in childhood. Int J Pediatr Otorhinolaryngol 61:265–268CrossRefPubMedGoogle Scholar
  15. 15.
    Mentzel T, Calonje E, Fletcher CD (1993) Lipoblastoma and lipoblastomatosis: a clinicopathological study of 14 cases. Histopathology 23:527–533PubMedCrossRefGoogle Scholar
  16. 16.
    Fletcher JA, Kozakewich HP, Schoenberg ML, Morton CC (1993) Cytogenetic findings in pediatric adipose tumors: consistent rearrangement of chromosome 8 in lipoblastoma. Genes Chrom Cancer 6:24–29PubMedCrossRefGoogle Scholar
  17. 17.
    Hicks J, Dilley A, Patel D, Barrish J, Zhu SH, Brandt ML (2001) Lipoblastoma and lipoblasmatosis in infancy and childhood: histopathologic, ultrastructural, and cytogenetic features. Ultrastruct Pathol 25:321–333CrossRefPubMedGoogle Scholar
  18. 18.
    Gaffney EF, Vellios F, Hargreaves HK (1986) Lipoblastomatosis: ultrastructure of two cases and relationship to human fetal white adipose tissue. Pediatr Pathol 5:207–216PubMedCrossRefGoogle Scholar
  19. 19.
    Van Meurs DP (1947) The transformation of an embryonic lipoma to a common lipoma. Br J Surg 34:282–284CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Shih-Ming Jung
    • 1
  • Pei-Yeh Chang
    • 2
  • Chih-Cheng Luo
    • 2
  • Chen-Sheng Huang
    • 2
  • Jin-Yao Lai
    • 2
  • Chuen Hsueh
    • 1
  1. 1.Department of Pathology, Chang Gung Memorial Hospital, Chang Gung Children’s HospitalChang Gung UniversityTaoyuanTaiwan
  2. 2.Department of Pediatric SurgeryChang Gung Children’s HospitalTaoyuanTaiwan

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