Pediatric Surgery International

, Volume 21, Issue 12, pp 947–953 | Cite as

Advances in short bowel syndrome: an updated review

  • Igor Sukhotnik
  • Arnold G. Coran
  • Alexander Kramer
  • Eitan Shiloni
  • Jorge G. Mogilner
Review Article

Abstract

Short bowel syndrome (SBS) continues to be an important clinical problem due to its high mortality and morbidity as well as its devastating socioeconomic effects. The past 3 years have witnessed many advances in the investigation of this condition, with the aim of elucidating the cellular and molecular mechanisms of intestinal adaptation. Such information may provide opportunities to exploit various factors that act as growth agents for the remaining bowel mucosa and may suggest new therapeutic strategies to maintain gut integrity, eliminate dependence on total parenteral nutrition, and avoid the need for intestinal transplantation. This review summarizes current research on SBS over the last few years.

Keywords

Intestine Adaptation Short bowel syndrome Research Intestinal growth 

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Igor Sukhotnik
    • 1
  • Arnold G. Coran
    • 2
    • 3
  • Alexander Kramer
    • 4
  • Eitan Shiloni
    • 4
  • Jorge G. Mogilner
    • 1
  1. 1.Department of Pediatric Surgery BBnai Zion Medical CenterHaifaIsrael
  2. 2.Carmel Medical Center, Rappaport Faculty of MedicineHaifaIsrael
  3. 3.Section of Pediatric Surgery, C.S. Mott Children’s HospitalUniversity of Michigan Medical SchoolAnn ArborUSA
  4. 4.Department of General SurgeryCarmel Medical Center, Rappaport Faculty of MedicineHaifaIsrael

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