Advertisement

Pediatric Surgery International

, Volume 21, Issue 8, pp 692–694 | Cite as

Pertussis with severe pulmonary hypertension and leukocytosis treated with extracorporeal membrane oxygenation

  • Brittany B. De Berry
  • James E. Lynch
  • Dai H. Chung
  • Joseph B. Zwischenberger
Case Report

Abstract

Pertussis, or “whooping cough,” is a highly communicable disease caused by the coccobacillus Bordetella pertussis. Pertussis remains one of the most common causes of death from infectious diseases worldwide. We describe a 5-week-old infant girl who presented with severe pertussis infection associated with extreme leukocytosis and required prolonged extracorporeal membrane oxygenation (ECMO). Nitric oxide therapy resolved the pulmonary hypertension, and she was successfully weaned from ECMO and discharged home after 3 months. We report successful application of ECMO for severe pertussis-induced respiratory failure despite multiple grave prognostic indicators (<1 year age, leukocytosis, pulmonary hypertension) and discuss the role of extracorporeal life support in treating pertussis.

Keywords

Pertussis Bordetella pertussis Leukocytosis Pulmonary hypertension ECMO 

References

  1. 1.
    von Konig CH, Halperin S, Riffelmann M et al (2002) Pertussis of adults and infants. Lancet Infect Dis 2:744–750CrossRefPubMedGoogle Scholar
  2. 2.
    Fung KS, Yeung WL, Wong TW et al (2004) Pertussis—a re-emerging infection? J Infect 48:145–148CrossRefPubMedGoogle Scholar
  3. 3.
    Pierce C, Klein N, Peters M (2000) Is leukocytosis a predictor of mortality in severe pertussis infection? Intensive Care Med 26:1512–1514CrossRefPubMedGoogle Scholar
  4. 4.
    Sreenan CD, Osiovich H (2001) Neonatal pertussis requiring extracorporeal membrane oxygenation. Pediatr Surg Int 17:201–203CrossRefPubMedGoogle Scholar
  5. 5.
    Kerr JR, Matthews RC (2000) Bordetella pertussis infection: pathogenesis, diagnosis, management, and the role of protective immunity. Eur J Clin Microbiol Infect Dis 19:77–88PubMedCrossRefGoogle Scholar
  6. 6.
    Halasa NB, Barr FE, Johnson JE et al (2003) Fatal pulmonary hypertension associated with pertussis in infants: does extracorporeal membrane oxygenation have a role? Pediatrics 112:1274–1278CrossRefPubMedGoogle Scholar
  7. 7.
    Bruss JB, Malley R, Halperin S et al (1999) Treatment of severe pertussis: a study of the safety and pharmacology of intravenous pertussis immunoglobulin. Pediatr Infect Dis J 18:505–511CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Brittany B. De Berry
    • 1
  • James E. Lynch
    • 1
  • Dai H. Chung
    • 1
  • Joseph B. Zwischenberger
    • 1
  1. 1.Department of SurgeryThe University of Texas Medical BranchGalvestonUSA

Personalised recommendations