Pediatric Surgery International

, Volume 20, Issue 10, pp 737–740

Topography, stem cell behaviour, and organogenesis

  • David Edgar
  • Simon Kenny
  • Sarah Almond
  • Patricia Murray
Review Article


The fundamental problem of development is to explain how the progeny of a single cell, the fertilised egg, differentiates to form all the tissues of the body in the right place at the right time. It has only been during the last couple of years that the mechanisms and molecules mediating interactions between cells and tissues have begun to be delineated. This article reviews some of these recent studies. Sequences of topoqraphically defined cellular interactions lead not only to the development of the body but also to the obvious and remarkable inference that the body more or less automatically builds itself.


Organogenesis Topography Stem cell Development 


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • David Edgar
    • 1
    • 2
  • Simon Kenny
    • 3
  • Sarah Almond
    • 3
  • Patricia Murray
    • 2
  1. 1.Human AnatomySherrington BuildingsLiverpoolUK
  2. 2.The University of Liverpool Department of Human AnatomyLiverpoolUK
  3. 3.The University of Liverpool Department of Paediatric SurgeryInstitute of Child Health, Alder Hey Children’s HospitalLiverpoolUK

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