Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Effect of liver transplantation on multiple bone fractures in an infant with end-stage biliary atresia: a case report

Abstract

Osteodystrophy is frequently found in children with chronic cholestatic liver disease. We herein report an end-stage case of biliary atresia that was associated with multiple bone fractures and severe growth retardation. The patient, an 8-month-old female, underwent a living-related liver transplantation and thereafter showed a dramatic improvement in growth and decrease in bone fractures. A correction of the liver function is therefore considered to be a key factor in treating osteodystrophy that is related to chronic cholestatic liver disease. It is also essential to perform liver transplantation at the most appropriate time to enhance and support the growth of these patients.

This is a preview of subscription content, log in to check access.

Fig. 1
Fig. 2

References

  1. 1.

    D’Antiga L, Moniz C, Buxton-Thomas M, Cheeseman P, Gray B, Abraha H, Baker AJ, Heaton ND, Rela M, Mieli-Vergani G, Dhawan A (2002) Bone mineral density and height gain in children with chronic cholestatic liver disease undergoing transplantation. Transplantation 73:1788–1793

  2. 2.

    Okajima H, Sigeno C, Inomata Y, Egawa H, Uemoto S, Asomuma K, Kiuchi T, Konishi J, Tanaka K (2003) Long-term effects of liver transplantation on bone mineral density in children with end-stage liver disease: a 2-year prospective study. Liver Transplantation 9:360–364

  3. 3.

    Argao EA, Specker BL, Heubi JE (1993) Bone mineral content in infants and children with chronic cholestatic liver disease. Pediatrics 91:1151–1154

  4. 4.

    Chongsrisawat V, Ruttanamongkol P, Chaiwatanarat T, Chandrakamol B, Poovorawan Y (2001) Bone density and 25-hydroxy vitamin D level in extrahepatic biliary atresia. Pediatr Surg Int 17:604–608

  5. 5.

    Compston JE (2003) The skeletal effect of liver transplantation in children. Liver Transplantation 9:371–372

  6. 6.

    Meyers L, Book LS, O’Gorman MA, Jackson WD, Black RE, Johnson DG, Matlak ME (2003) High-dose steroids, ursodeoxycholic acid, and chronic intravenous antibiotics improve bile flow after Kasai procedure in infants with biliary atresia. J Pediatr Surg 38:406–411

Download references

Author information

Correspondence to Sachiyo Suita.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Katsura, S., Ogita, K., Taguchi, T. et al. Effect of liver transplantation on multiple bone fractures in an infant with end-stage biliary atresia: a case report. Ped Surgery Int 21, 47–49 (2005). https://doi.org/10.1007/s00383-004-1262-z

Download citation

Keywords

  • Biliary atresia (BA)
  • Bone fractures
  • Living-related liver transplantation (LRLT)