Child’s Nervous System

, Volume 17, Issue 9, pp 519–523 | Cite as

Perfusion brain scintigraphy studies in infants and children with malformations of the vein of Galen

  • Ruth Nass
  • Elissa Kramer
  • Walter Molofsky
  • Jon Melnick
  • Marilyn de Hollisey
  • Mary Madrid
  • Jeffrey H. Wisoff
  • Alejandro Berenstein
Brief Communication

Abstract.

Cerebral perfusion brain scintigraphy obtained in six unselected patients (age newborn to 14 years) from among 50 children with vein of Galen malformations was used in conjunction with magnetic resonance imaging to determine the basis of the neurological and cognitive abnormalities in patients with vein of Galen malformations (VGMs). Five had a hemiparesis – persistent, transient, or alternating. Four were developmentally delayed. Two had so far been cognitively normal and acquired a neurological deficit, following an embolization procedure. The school age patient had a nonverbal learning disability. Three had epilepsy and/or an abnormal electroencephalogram. Magnetic resonance imaging documented only the VGM, hydrocephalus and atrophy; one child with perinatal asphyxia had periventricular leukomalacia. Perfusion brain scintigraphy was normal in two (a normal infant, and a toddler with a hemiparesis and aphasia). Abnormal findings included: left parietal hypoperfusion, fronto-temporal atrophy, patchy flow; left fronto-temporal hypoperfusion, left hemiatrophy, bilateral medial temporal hypoperfusion, right cerebellar hypoperfusion; right temporal hypoperfusion, patchy flow; right hemiatrophy, occipital hypoperfusion. Perfusion brain scintigraphy findings correlated better with focal neurological and cognitive defects than did magnetic resonance imaging.

Magnetic resonance imaging Perfusion brain scintigraphy Vein of Galen malformations 

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Ruth Nass
    • 1
  • Elissa Kramer
    • 3
  • Walter Molofsky
    • 4
  • Jon Melnick
    • 2
  • Marilyn de Hollisey
    • 5
  • Mary Madrid
    • 6
  • Jeffrey H. Wisoff
    • 6
  • Alejandro Berenstein
    • 3
  1. 1.Pediatric Neurology, New York University Medical CenterNew York, NYUSA
  2. 2.Department of Neurology, New York University Medical CenterNew York, NYUSA
  3. 3.Department of Neuroradiology, New York University Medical CenterNew York, New YorkUSA
  4. 4.Department of Neurology, Beth Israel Medical CenterNew York, New YorkUSA
  5. 5.Department of Neurology, VA HospitalNew York, New YorkUSA
  6. 6.Department of Neurosurgery, New York University Medical CenterNew York, New YorkUSA

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