Child's Nervous System

, Volume 14, Issue 6, pp 247–255

A rabbit model of human familial, nonsyndromic unicoronal suture synostosis II. Intracranial contents, intracranial volume, and intracranial pressure

II. Intracranial contents, intracranial volume, and intracranial pressure
  • M. P. Mooney
  • Michael I. Siegel
  • Annie M. Burrows
  • Timothy D. Smith
  • H. Wolfgang Losken
  • J. Dechant
  • Gregory Cooper
  • Wendy Fellows-Mayle
  • M. Rusen Kapucu
  • L. Ozlem Kapucu
ORIGINAL PAPER

DOI: 10.1007/s003810050220

Cite this article as:
Mooney, M., Siegel, M., Burrows, A. et al. Child's Nerv Syst (1998) 14: 247. doi:10.1007/s003810050220

Abstract

This two-part study reviews data from a recently developed colony of New Zealand white rabbits with familial, nonsyndromic unilateral coronal suture synostosis, and this second part presents neuropathological findings and age-related changes in intracranial volume (ICV) and intracranial pressure (ICP) in 106 normal rabbits and 56 craniosynostotic rabbits from this colony. Brain morphology and anteroposterior length were described in 44 rabbit fetuses and perinates (27 normal; 17 synostosed). Middle meningeal artery patterns were qualitatively assessed from 2-D PCC MRI VENC scans and endocranial tracings from 15, 126-day-old rabbits (8 normal, 7 rabbits with unicoronal synostosis). Brain metabolism was evaluated by assessing 18F-FDG uptake with high-resolution PET scanning in 7, 25-day-old rabbits (3 normal, 4 with unicoronal or bicoronal synostosis). Intracranial contents and ICV were assessed using 3-D CT scanning of the skulls of 30 rabbits (20 normal,10 with unicoronal synostosis) at 42 and 126 days of age. Serial ICP data were collected from 66 rabbits (49 normal; 17 with unicoronal synostosis) at 25 and 42 days of age. ICP was assessed in the epidural space using a Codman NeuroMonitor microsensor transducer. Results revealed that cerebral cortex morphology was similar between normal and synostosed fetuses around the time of synostosis. Significantly (P<0.05) decreased A-P cerebral hemisphere growth rates and asymmetrical cortical remodeling were noted with increasing age in synostotic rabbits. In addition, rabbits with unicoronal suture synostosis exhibited asymmetrical middle meningeal artery patterns, decreased and asymmetrical brain metabolism, a “beaten-copper” intracranial appearance, significantly (P<0.05) decreased ICV, and significantly (P<0.01) elevated ICP compared with normal control rabbits. The advantages and disadvantages of these rabbits as a model for human familial, nonsyndromic unicoronal suture synostosis are discussed, especially in light of recent clinical neuropathological, ICV, and ICP findings recorded in human craniosynostotic studies.

Key words Plagiocephaly Rabbit model Intracranial pressure Intracranial volume Brain 

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • M. P. Mooney
    • 1
  • Michael I. Siegel
    • 2
  • Annie M. Burrows
    • 2
  • Timothy D. Smith
    • 2
  • H. Wolfgang Losken
    • 3
  • J. Dechant
    • 2
  • Gregory Cooper
    • 1
  • Wendy Fellows-Mayle
    • 2
  • M. Rusen Kapucu
    • 3
  • L. Ozlem Kapucu
    • 8
  1. 1.Department of Anatomy and Histology, 619 Salk Hall, University of Pittsburgh, Pittsburgh, PA 15261, USAUSA
  2. 2.Department of Anthropology, University of Pittsburgh, Pittsburgh, PA 15261, USAUSA
  3. 3.Department of Plastic and Reconstructive Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USAUSA
  4. 4.Department of Orthodontics, University of Pittsburgh, Pittsburgh, PA 15261, USAUSA
  5. 5.Cleft Palate-Craniofacial Center, University of Pittsburgh, Pittsburgh, PA 15261, USAUSA
  6. 6.Department of Physical Therapy, Slippery Rock University, Slippery Rock, Pennsylvania, USAUSA
  7. 7.Department of Pediatric Plastic Surgery, Children's Hospital, Pittsburgh, Pennsylvania, USAUSA
  8. 8.Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15261, USAUSA
  9. 9.Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA 15261, USAUSA

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