Child's Nervous System

, Volume 35, Issue 12, pp 2423–2426 | Cite as

Pure germinoma occurring 11 years after total pineal mature teratoma removal: a case report and review of the literature

  • Kazuki Sakakura
  • Ai MuroiEmail author
  • Takao Tsurubuchi
  • Shingo Takano
  • Eiichi Ishikawa
  • Akira Matsumura
Case Report


Intracranial mature teratomas have good prognoses and are usually treated by total tumor resection. We report a rare case of a germinoma that occurred 11 years after total removal of a pineal mature teratoma. A 5-year-old boy presented with headache and nausea and was diagnosed with a pineal tumor and obstructive hydrocephalus on MRI. He underwent total removal of the lesion, which was pathologically diagnosed as a mature teratoma without any other germ cell tumor components. MR images after 11 years showed a newly developed pineal tumor, which was confirmed as a germinoma after neuroendoscopic biopsy. Chemoradiotherapy resulted in complete remission, without any symptoms. This case demonstrated possible late occurrence of germinoma even after total removal of a mature teratoma had been achieved. A long-term follow-up of 10 years or more should be planned for these patients.


Mature teratoma Pure germinoma Primordial germ cell Germ cell tumor 



The authors would like to thank Dr. Noriaki Sakamoto for preparing the histopathology photo. We would like to thank Editage ( for English language editing.


This study did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Neurosurgery, Faculty of MedicineUniversity of TsukubaIbarakiJapan

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