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Child's Nervous System

, Volume 35, Issue 9, pp 1579–1583 | Cite as

Analysis of serial electroencephalographic predictors of seizure recurrence in Rolandic epilepsy

  • Hongwei Tang
  • Yanping Wang
  • Ying Hua
  • Jianbiao Wang
  • Miao Jing
  • Xiaoyue HuEmail author
Original Article

Abstract

Purpose

We aimed to assess the relationship between electroencephalography (EEG) markers and seizure recurrence in cases with benign epilepsy with centrotemporal spikes (BECT) in a long-term follow-up study.

Methods

We analyzed the data of 52 children with BECT who were divided into 2 groups: the isolated group and recurrence group. The clinical profiles and initial/serial visual EEG recordings of both groups were evaluated. The entire follow-up period ranged from 12 to 65 months.

Results

None of the clinical characteristics differed between the 2 groups. Serial EEGs showed that the appearance of Rolandic spikes in the frontal region was more prevalent in the recurrence group. Moreover, a significant correlation was found between bilateral asynchronous discharges and seizure recurrence. However, on initial EEG of these patients, neither of the EEG features exhibited statistical significance.

Conclusion

The presence of frontal focus and bilateral asynchrony appeared to be hallmarks of BECT patients with higher risk for seizure recurrence.

Keywords

BECT Rolandic epilepsy EEG Seizure 

Abbreviations

EEG

electroencephalography

BECT

Benign epilepsy with centrotemporal spikes

MRI

Magnetic resonance imaging

AEDs

Antiepileptic drugs

LEV

Levetiracetam

OXC

Oxcarbazepine

VPA

Valproate

CZP

Clonazepam

OR

Odds ratio

CI

Confidence interval

NS

Not significant

Notes

Funding information

This work was supported by Wuxi Young Medical Talents (Grant Number QNRC021); Medical Innovation Team of Jiangsu Province (Grant Number CXTDB2017016); and Wuxi Medical Development Discipline (Grant Number FZXK001).

Compliance with ethical standards

Conflict of interest

The authors declare that there is no conflict of interest.

References

  1. 1.
    Arhan E, Serdaroglu A, Ozturk Z, Aydin K, Hirfanoglu T (2018) Serial changes in the paroxysmal discharges in rolandic epilepsy may predict seizure recurrence: a retrospective 3-year follow-up study. Epilepsy Behav 82:150–154.  https://doi.org/10.1016/j.yebeh.2018.03.014 CrossRefGoogle Scholar
  2. 2.
    Bouma PA, Bovenkerk AC, Westendorp RG, Brouwer OF (1997) The course of benign partial epilepsy of childhood with centrotemporal spikes: a meta-analysis. Neurology 48:430–437CrossRefGoogle Scholar
  3. 3.
    Callenbach PM, Bouma PA, Geerts AT, Arts WF, Stroink H, Peeters EA, van Donselaar CA, Peters AC, Brouwer OF (2010) Long term outcome of benign childhood epilepsy with centrotemporal spikes: Dutch study of epilepsy in childhood. Seizure 19:501–506.  https://doi.org/10.1016/j.seizure.2010.07.007 CrossRefGoogle Scholar
  4. 4.
    Cibula JE, Gilmore RL (1997) Secondary epileptogenesis in humans. J Clin Neurophysiol 14:111–127CrossRefGoogle Scholar
  5. 5.
    Datta A, Sinclair DB (2007) Benign epilepsy of childhood with rolandic spikes: typical and atypical variants. Pediatr Neurol 36:141–145.  https://doi.org/10.1016/j.pediatrneurol.2006.12.003 CrossRefGoogle Scholar
  6. 6.
    de Saint-Martin A, Petiau C, Massa R, Maquet P, Marescaux C, Hirsch E, Metz-Lutz MN (1999) Idiopathic rolandic epilepsy with "interictal" facial myoclonia and oromotor deficit: a longitudinal EEG and PET study. Epilepsia 40:614–620CrossRefGoogle Scholar
  7. 7.
    Fejerman N, Caraballo R, Tenembaum SN (2000) Atypical evolutions of benign partial epilepsy of infancy with centro-temporal spikes. Rev Neurol 31:389–396Google Scholar
  8. 8.
    Kanemura H, Sano F, Aoyagi K, Sugita K, Aihara M (2012) Do sequential EEG changes predict atypical clinical features in rolandic epilepsy? Dev Med Child Neurol 54:912–917.  https://doi.org/10.1111/j.1469-8749.2012.04358.x CrossRefGoogle Scholar
  9. 9.
    Kanemura H, Sano F, Ohyama T, Sugita K, Aihara M (2014) Sequential EEG characteristics may predict seizure recurrence in rolandic epilepsy. Seizure 23:646–650.  https://doi.org/10.1016/j.seizure.2014.05.006 CrossRefGoogle Scholar
  10. 10.
    Kellaway P (2000) The electroencephalographic features of benign centrotemporal (rolandic) epilepsy of childhood. Epilepsia 41:1053–1056CrossRefGoogle Scholar
  11. 11.
    Loiseau P, Duche B, Cordova S, Dartigues JF, Cohadon S (1988) Prognosis of benign childhood epilepsy with centrotemporal spikes: a follow-up study of 168 patients. Epilepsia 29:229–235CrossRefGoogle Scholar
  12. 12.
    Massa R, de Saint-Martin A, Carcangiu R, Rudolf G, Seegmuller C, Kleitz C, Metz-Lutz MN, Hirsch E, Marescaux C (2001) EEG criteria predictive of complicated evolution in idiopathic rolandic epilepsy. Neurology 57:1071–1079CrossRefGoogle Scholar
  13. 13.
    Ong HT, Wyllie E (2000) Benign childhood epilepsy with centrotemporal spikes: is it always benign? Neurology 54:1182–1185CrossRefGoogle Scholar
  14. 14.
    Riva D, Vago C, Franceschetti S, Pantaleoni C, D'Arrigo S, Granata T, Bulgheroni S (2007) Intellectual and language findings and their relationship to EEG characteristics in benign childhood epilepsy with centrotemporal spikes. Epilepsy Behav 10:278–285.  https://doi.org/10.1016/j.yebeh.2006.12.003 CrossRefGoogle Scholar
  15. 15.
    Sarco DP, Boyer K, Lundy-Krigbaum SM, Takeoka M, Jensen F, Gregas M, Waber DP (2011) Benign rolandic epileptiform discharges are associated with mood and behavior problems. Epilepsy Behav 22:298–303.  https://doi.org/10.1016/j.yebeh.2011.06.023 CrossRefGoogle Scholar
  16. 16.
    Staden U, Isaacs E, Boyd SG, Brandl U, Neville BG (1998) Language dysfunction in children with Rolandic epilepsy. Neuropediatrics 29:242–248.  https://doi.org/10.1055/s-2007-973569 CrossRefGoogle Scholar
  17. 17.
    Vannest J, Tenney JR, Gelineau-Morel R, Maloney T, Glauser TA (2015) Cognitive and behavioral outcomes in benign childhood epilepsy with centrotemporal spikes. Epilepsy Behav 45:85–91.  https://doi.org/10.1016/j.yebeh.2015.01.041 CrossRefGoogle Scholar
  18. 18.
    Watemberg N, Afunevitz S, Ganelin-Cohen E, Mahajnah M (2018) Clinical features at the time of diagnosis of benign epilepsy with centrotemporal spikes do not predict subsequent seizures. Pediatr Neurol 88:36–39.  https://doi.org/10.1016/j.pediatrneurol.2018.08.024 CrossRefGoogle Scholar
  19. 19.
    Weglage J, Demsky A, Pietsch M, Kurlemann G (1997) Neuropsychological, intellectual, and behavioral findings in patients with centrotemporal spikes with and without seizures. Dev Med Child Neurol 39:646–651CrossRefGoogle Scholar
  20. 20.
    Wirrell EC (1998) Benign epilepsy of childhood with centrotemporal spike. Epilepsia 39:32–41CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NeurologyWuxi Children’s HospitalWuxiChina

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