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Child's Nervous System

, Volume 35, Issue 5, pp 833–841 | Cite as

Upward movement of cerebrospinal fluid in obstructive hydrocephalus—revision of an old concept

  • Hans C. Bock
  • Steffi F. Dreha-Kulaczewski
  • Awad Alaid
  • Jutta Gärtner
  • Hans C. LudwigEmail author
Original Article

Abstract

Purpose

The specific pathophysiological processes in many forms of obstructive hydrocephalus (HC) are still unclear. Current concepts of cerebrospinal fluid (CSF) dynamics presume a constant downward flow from the lateral ventricles towards subarachnoid spaces, which are in contrast to neurosurgical observations and findings of MRI flow studies. The aim of our study was to analyze CSF movements in patients with obstructive HC by neuroendoscopic video recordings, X-ray studies, and MRI.

Methods

One hundred seventeen pediatric patients with obstructive HC who underwent neuroendoscopy in our center were included. Video recordings were analyzed in 85 patients. Contrast-enhanced X-rays were conducted during surgery prior to intervention in 75 patients, and flow void signals on pre-operative MRI could be evaluated in 110 patients.

Results

In 83.5% of the video recordings, CSF moved upwards synchronous to inspiration superimposed by cardiac pulsation. Application of contrast medium revealed a flow delay in 52% of the X-ray studies prior to neurosurgery, indicating hindered CSF circulation. The appearances and shapes of flow void signals in 88.2% of the pre-operative MRI studies suggested valve-like mechanisms and entrapment of CSF.

Conclusions

Neuroendoscopic observations in patients with obstructive HC revealed upward CSF movements and the corresponding MRI signs of trapped CSF in brain cavities. These observations are in contrast to the current pathophysiological concept of obstructive HC. However, recent real-time flow MRI studies demonstrated upward movement of CSF, hence support our clinical findings. The knowledge of cranial-directed CSF flow expands our understanding of pathophysiological mechanisms in HC and is the key to effective treatment.

Keywords

Hydrocephalus Neuroendoscopy Real-time flow MR imaging CSF dynamics 

Notes

Conflict of interest

The authors declare that they have no competing interest.

Author contributions

HCB and AA performed the endoscopic part of the studies. HCL designed the study, conducted the study including endoscopies, and wrote the manuscript. SDK conducted the study and wrote the manuscript. JG conducted the study and wrote the manuscript.

Supplementary material

381_2019_4119_MOESM1_ESM.docx (47 kb)
Supplementary table : Clinical data of 117 pediatric patients with obstructive hydrocephalus and assessment of pre-, intra-, and post-operative CSF dynamics. MRI category: see Table II; G: gender; yrs: years; HC: hydrocephalus; Intraop.: intraoperative; CM: contrast medium; X-ray: C-arc X-ray; m: male; f: female; OH: obstructive hydrocephalus; LH: loculated hydrocephalus; TU: tumor related hydrocephalus; iso4 v: isolated 4th ventricle; AC: arachnoid cyst; CF: cyst fenestration; ETV: endoscopic third ventriculostomy; SP: pellucidotomy; AP: aqueductoplasty; 1: yes; 0: no; NA: not applicable; *: of CSF; **: prior to surgical intervention (DOCX 46 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Hans C. Bock
    • 1
  • Steffi F. Dreha-Kulaczewski
    • 2
  • Awad Alaid
    • 1
  • Jutta Gärtner
    • 2
  • Hans C. Ludwig
    • 1
    Email author
  1. 1.Department of Neurosurgery, Section Pediatric NeurosurgeryUniversity Medical Center GöttingenGöttingenGermany
  2. 2.Department of Pediatrics and Adolescent Medicine, Division of Pediatric NeurologyUniversity Medical Center GöttingenGöttingenGermany

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