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Child's Nervous System

, Volume 35, Issue 3, pp 463–468 | Cite as

Factors affecting epilepsy prognosis in patients with tuberous sclerosis

  • Gülen Gül MertEmail author
  • Şakir Altunbaşak
  • Özlem Hergüner
  • Faruk İncecik
  • Hilal Cansever Övetti
  • Neslihan Özcan
  • Duygu Kuşçu
  • İlker Ünal
Original Article

Abstract

Purpose

We aimed to determine the characteristics of epileptic seizures that significantly affect the cognitive functions of 83 patients followed with tuberous sclerosis complex (TSC), their resistance to treatment and risk factors causing this resistance.

Materials-methods

In order to determine the prognosis, the seizure-free/seizure-controlled group and the group with refractory seizures were compared. In addition, risk factors affecting cognitive functions in the patients were determined.

Results

There was a statistical significance between the presence of a history of seizures in the neonatal period, the age of onset of seizures being less than 2 years of age, autism, status epilepticus, Lennox-Gastaut syndrome (LGS), presence of infantile spasm, generalization of the electroencephalography (EEG) findings, the number of tubers in cerebral imaging being more than three and refractory seizures (p < 0.05). Statistically significant relationship was found between presence of a history of seizures in the neonatal period, the age of onset of seizures, autism, LGS, presence of infantile spasm, presence of status epilepticus history, history of using more than three antiepileptic drugs, generalization of EEG findings, presence of SEGA in cerebral imaging, number of tubers being more than three and the patient’s mental retardation (p < 0.05).

Conclusion

In logistic regression analysis, the age of the seizure onset being less than 2 years of age, the presence of autism and number of tubers being more than three in cerebral magnetic resonance imaging (MRI) are determined to be the risk factors that most likely to increase the seizures to be more resistant.

Keywords

Tuberous sclerosis Epilepsy Prognosis 

Notes

Compliance with ethical standards

On June 1, 2018, under the decree no 72, ethic committee approval of the study from Cukurova University Faculty of Medicine Non-Interventional Clinical Trials Ethics Committee and consent from the families of the patients to participate in the study were obtained

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Gülen Gül Mert
    • 1
    Email author
  • Şakir Altunbaşak
    • 1
  • Özlem Hergüner
    • 1
  • Faruk İncecik
    • 1
  • Hilal Cansever Övetti
    • 1
  • Neslihan Özcan
    • 1
  • Duygu Kuşçu
    • 2
  • İlker Ünal
    • 3
  1. 1.Department of Pediatrics, Division of Pediatric NeurologyCukurova UniversityAdanaTurkey
  2. 2.Department of PsychologyCukurova UniversityAdanaTurkey
  3. 3.Department of BiostatisticsCukurova UniversityAdanaTurkey

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