Child's Nervous System

, Volume 35, Issue 2, pp 277–282 | Cite as

Lack of relationship between cord blood erythropoietin and intraventricular hemorrhage in premature neonates: a controversial result

  • Khadijehsadat Najib
  • Zahra Hashemi
  • Mozhgan MoghtaderiEmail author
  • Parisa Pishdad
  • Narjes Pishva
  • Fatemehsadat Najib
Original Paper



The aim of this study was to assess the incidence and risk factors of intraventricular hemorrhage (IVH) as well as the role of cord blood erythropoietin (EPO) level in predicting the possibility of IVH in premature neonates.

Materials and methods

This prospective study included 140 preterm neonates born at hospitals affiliated to Shiraz University of Medical Sciences from May 2014 to April 2015. Complete blood count and cord blood EPO level was measured after birth. Brain ultrasonography was performed at 3 and 7–10 days after birth in these newborns.


Brain ultrasonography showed IVH in 8.57% (12/140) until the third day and 20% (28/140) at 7–10 days of life in premature neonates. Early gestational age, low birth weight, low Apgar score, and failure to give prenatal steroid were significant risk factors for developing IVH. The mean level of cord blood EPO was 20.95 ± 21.09 mIU/mL in premature newborns without IVH and 15.82 ± 17.11 mIU/mL with IVH. There was no correlation between the cord blood EPO and IVH in premature newborns.


Antenatal steroids therapy should be encouraged among women at risk of premature delivery. Our results showed that the cord blood EPO was not correlated with IVH in preterm neonates and further research is required to assess this relationship.


Premature Intraventricular hemorrhage Erythropoietin Risk factors 



We are thankful to all the parents who took part in this study. The authors would like to thank Shiraz University of Medical Sciences, Shiraz, Iran and also Center for Development of Clinical Research of Nemazee Hospital and Dr. Nasrin Shokrpour for editorial assistance.


Najib Kh contributed to the conception, design, and analysis the data and wrote the paper; Hashemi Z and Pishva N contributed to the design of the research study and analysis of data; Moghtaderi M contributed to the statistical analysis of the data, drafting and writing the article; Pishdad P performed the brain sonography and writing; and Najib Fs examined the newborns and wrote the article. Each author contributed to revisions of the manuscript and approval of the final version.

Funding information

This work was supported by a grant from Shiraz University of Medical Sciences (7369-21-01-93).

Compliance with ethical standards

Conflict of interest

No conflict of interest is declared.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Khadijehsadat Najib
    • 1
  • Zahra Hashemi
    • 1
  • Mozhgan Moghtaderi
    • 2
    Email author
  • Parisa Pishdad
    • 3
  • Narjes Pishva
    • 1
  • Fatemehsadat Najib
    • 4
  1. 1.Neonatal Research Center, Pediatric DepartmentShiraz University of Medical SciencesShirazIran
  2. 2.Allergy Research CenterShiraz University of Medical SciencesShirazIran
  3. 3.Radiologic DepartmentShiraz University of Medical SciencesShirazIran
  4. 4.Gynecology and Obstetrics DepartmentShiraz University of Medical SciencesShirazIran

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