Child's Nervous System

, Volume 34, Issue 8, pp 1445–1446 | Cite as

Intracerebral juvenile xanthogranuloma: an infrequent involvement of hystiocitosis in children

  • P. Torres PérezEmail author
  • A. Bollar Zabala
  • M. Armendáriz Guezala
  • E. Úrculo Bareño
Letter to the Editor

Dear Editor:

Juvenile xanthogranuloma (JXG) is an uncommon disorder of histiocytic non-Langerhans cell type with cutaneous manifestations, which often occurs in children and usually has a benign clinical course [1]. Extracutaneous involvement is rare (4%), it mainly occurs within the eye, bone, lung, muscles, and liver and even more uncommon, involving the central nervous system (1–2%) [2, 3]; therefore, we consider of interest to present a 6-year-old girl diagnosed with disseminated JXG 5 years ago, who presented an intracerebral tumor during her follow-up.

The diagnosis was incidental, after several episodes of osteomyelitis with acromial pain and fever. A complete study of Rx, TC scan, and positron emission tomography-TC pelvic-chest-bone series showed multiple nodular and hypermetabolic lesions with bone and visceral implication: both lungs, liver, osteolytic lesions in skull bone, iliac blades, ribs, and lumbar vertebral bodies.

A cerebral MRI was performed to complete the...


Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurosurgeryHospital Universitario DonostiaSan SebastiánSpain

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