Intracerebral juvenile xanthogranuloma: an infrequent involvement of hystiocitosis in children
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Juvenile xanthogranuloma (JXG) is an uncommon disorder of histiocytic non-Langerhans cell type with cutaneous manifestations, which often occurs in children and usually has a benign clinical course . Extracutaneous involvement is rare (4%), it mainly occurs within the eye, bone, lung, muscles, and liver and even more uncommon, involving the central nervous system (1–2%) [2, 3]; therefore, we consider of interest to present a 6-year-old girl diagnosed with disseminated JXG 5 years ago, who presented an intracerebral tumor during her follow-up.
The diagnosis was incidental, after several episodes of osteomyelitis with acromial pain and fever. A complete study of Rx, TC scan, and positron emission tomography-TC pelvic-chest-bone series showed multiple nodular and hypermetabolic lesions with bone and visceral implication: both lungs, liver, osteolytic lesions in skull bone, iliac blades, ribs, and lumbar vertebral bodies.
A cerebral MRI was performed to complete the...
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Conflict of interest
On behalf of all authors, the corresponding author states that there is no conflict of interest.