Child's Nervous System

, Volume 33, Issue 5, pp 825–827 | Cite as

Otto Mennicke (1876–) and the first description of skull base anomalies causing cerebellar tonsillar ectopia: one of the first mentions of the Chiari I malformation

  • Fabian N. Fries
  • Philipp Hendrix
  • Titus J. Brinker
  • Marios Loukas
  • R. Shane TubbsEmail author
Original Paper



Although Hans Chiari made significant and meaningful contributions to our understanding and classification of hindbrain herniations, others have also contributed to this knowledge. One figure who has been lost to history is Otto Mennicke. Herein, we discuss his role in our understanding of tonsillar ectopia and his life and connection to Hans Chiari.


Our knowledge of what is now known as the Chiari malformations has been shaped by several clinicians including Otto Mennicke.


Chiari I malformation Felix Marchand Otto Mennicke History of pathology 



The authors express their sincere gratitude to Ms. Claudia Lydorf for her assistance collecting the bibliographic data and to the University of Marburg, Germany, for providing us Mennicke’s dissertation Ueber Syringomyelie mit anatomischer Untersuchung zweier Fälle (Fig. 1).

Compliance with ethical standards


FNF holds a scholarship of the German Academic Exchange Service.

Conflict of interest

The authors declare that they have no conflicts of interest.


  1. 1.
    Chiari H (1891) Über Veränderungen des Kleinhirns in Folge von Hydrocephalie des Grosshirns (concerning alterations in the cerebellum resulting from cerebral hydrocephalus). Dtsch Med Wochenschr 17:1172–1175CrossRefGoogle Scholar
  2. 2.
    Chiari H (1896) Über Veränderungen des Kleinhirns, des Pons und Medulla oblongata in Folge von congenitaler Hydrocephalie des Grosshirns (Concerning alterations in the cerebellum, the pons and the medulla oblongata resulting from congenital cerebral hydrocephalus). Denkschr Kaiserl Akad Wiss Math NaturwGoogle Scholar
  3. 3.
    Eichhorst H, Naunyn B, Eichhorst H (1874) Ueber die Regeneration und Veränderungen im Rückenmarke nach streckenweiser totaler Zerstörung desselben. Archiv für experimentelle Pathologie und Pharmakologie 2:225–253. doi: 10.1007/bf01976870 Google Scholar
  4. 4.
    Kronthal P (1889) Zur Pathologie der Höhlenbildung im Rückenmark. Neurolog Centralblatt On Pathology of cavity creation in the spinal cordGoogle Scholar
  5. 5.
    Langhans T (1881) Ueber Höhlenbildung im Rückenmark als Folge von Blutstauung (regarding cavity creation in the spinal cord as a consequence of obstruction to blood flow). Virchows Arch Pathol Anat Physiol Klin Med 85:1–25. doi: 10.1007/BF01921341 CrossRefGoogle Scholar
  6. 6.
    Mennicke O (1891) Ueber Syringomyelie mit anatomischer Untersuchung zweier Fälle. Inaugural-Dissertation zur Erlangung der medicinischen Doktorwürde der hohen medicinischen Fakultät der Universität MarburgGoogle Scholar
  7. 7.
    Mortazavi MM, Tubbs RS, Brockerhoff MA, Loukas M, Oakes WJ (2011) The first description of Chiari I malformation with intuitive correlation between tonsillar ectopia and syringomyelia. J Neurosurg Pediatr 7:257–260CrossRefPubMedGoogle Scholar
  8. 8.
    Cesmebasi A, Loukas M, Hogan E, Kralovic S, Tubbs RS, Cohen-Gadol AA (2015) Clin Anat 28:184–194CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Fabian N. Fries
    • 1
    • 2
  • Philipp Hendrix
    • 1
    • 2
  • Titus J. Brinker
    • 3
    • 4
  • Marios Loukas
    • 5
  • R. Shane Tubbs
    • 5
    • 6
    Email author
  1. 1.Saarland University Medical CenterHomburgGermany
  2. 2.Faculty of MedicineSaarland UniversitySaarbrückenGermany
  3. 3.Department of Medical Oncology, West German Cancer CenterEssen University HospitalEssenGermany
  4. 4.University Duisburg-EssenEssenGermany
  5. 5.Department of Anatomical SciencesSt. George’s UniversitySt. George’sGrenada
  6. 6.Seattle Science FoundationSeattleUSA

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