Child's Nervous System

, Volume 32, Issue 11, pp 2219–2224 | Cite as

Association of nerve conduction impairment and insulin resistance in children with obesity

  • Onur AkınEmail author
  • İbrahim Eker
  • Mutluay Arslan
  • Serdar Taşdemir
  • Mehmet Emre Taşçılar
  • Ümit Hıdır Ulaş
  • Ediz Yeşilkaya
  • Bülent Ünay
Original Paper



The objective of our study was to investigate nerve conduction in normoglycemic obese children.


A total of 60 children with obesity (30 female and 30 male) and 30 healthy children (15 female and 15 male) were enrolled in the study. Insulin resistance (IR) and other metabolic disturbances were investigated and nerve conduction was measured in all participants. Obese children were divided into groups according to the presence of IR. All results were compared between these subgroups.


The nerve conduction velocity (NCV) of motor median nerves in the IR+ group was significantly higher than that in the IR− group and lower than that in the control group. The NCV of the motor peroneal nerve in the IR+ group was significantly lower than that in the IR− group. The sensory nerve action potential (SNAP) of the sensory median nerve was significantly lower in the IR+ group compared to that in the IR− group. The sensory sural nerve’s SNAP was significantly lower in the IR+ group than that in the control group.


Nerve conduction tests may help to detect early pathologies in peripheral nerves and to decrease morbidities in obese children.


Children Obesity Nerve conduction study 


Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.


  1. 1.
    Unger R, Kreeger L, Christoffel KK (1990) Childhood obesity. Medical and familial correlates and age of onset. Clin Pediatr (Phila) 29:368–373CrossRefGoogle Scholar
  2. 2.
    Twarog JP, Politis MD, Woods EL, Daniel LM, Sonneville KR (2016) Is obesity becoming the new normal? Age, gender and racial/ethnic differences in parental misperception of obesity as being ‘About the Right Weight’. International journal of obesityGoogle Scholar
  3. 3.
    Mielke JG, Taghibiglou C, Wang YT (2006) Endogenous insulin signaling protects cultured neurons from oxygen-glucose deprivation-induced cell death. Neuroscience 143:165–173CrossRefPubMedGoogle Scholar
  4. 4.
    Diaz B, Pimentel B, de Pablo F, de La Rosa EJ (1999) Apoptotic cell death of proliferating neuroepithelial cells in the embryonic retina is prevented by insulin. Eur J Neurosci 11:1624–1632CrossRefPubMedGoogle Scholar
  5. 5.
    Plum L, Schubert M, Bruning JC (2005) The role of insulin receptor signaling in the brain. Trends Endocrinol Metab 16:59–65CrossRefPubMedGoogle Scholar
  6. 6.
    Marks DR, Tucker K, Cavallin MA, Mast TG, Fadool DA (2009) Awake intranasal insulin delivery modifies protein complexes and alters memory, anxiety, and olfactory behaviors. J Neurosci 29:6734–6751CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Dietz WH, Robinson TN (2005) Clinical practice. Overweight children and adolescents. N Engl J Med 352:2100–2109CrossRefPubMedGoogle Scholar
  8. 8.
    Gordon Smith A, Robinson Singleton J (2006) Idiopathic neuropathy, prediabetes and the metabolic syndrome. J Neurol Sci 242:9–14CrossRefPubMedGoogle Scholar
  9. 9.
    Ince H, Tasdemir HA, Aydin M, Ozyurek H, Tilki HE (2015) Evaluation of nerve conduction studies in obese children with insulin resistance or impaired glucose tolerance. J Child Neurol 30:989–999CrossRefPubMedGoogle Scholar
  10. 10.
    Neyzi O, Bundak R, Gokcay G, Gunoz H, Furman A, Darendeliler F, Bas F (2015) Reference values for weight, height, head circumference, and body mass index in Turkish children. Journal of clinical research in pediatric endocrinology 7:280–293CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Neyzi O, Gunoz H, Furman A, Bundak R, Gökçay G, Darendeliler F, Baş F (2008) Weight, height, head circumference and body mass index references for Turkish children. Cocuk Saglıgı ve Hastalıkları Dergisi 51:1–14Google Scholar
  12. 12.
    Valerio G, Licenziati MR, Iannuzzi A, Franzese A, Siani P, Riccardi G, Rubba P (2006) Insulin resistance and impaired glucose tolerance in obese children and adolescents from Southern Italy. Nutr Metab Cardiovasc Dis 16:279–284CrossRefPubMedGoogle Scholar
  13. 13.
    Reinehr T, Kiess W, Kapellen T, Andler W (2004) Insulin sensitivity among obese children and adolescents, according to degree of weight loss. Pediatrics 114:1569–1573CrossRefPubMedGoogle Scholar
  14. 14.
    Polat M, Tekgul H, Kilincer A, Tosun A, Terlemez S, Serdaroglu G, Uludag B, Gokben S (2006) Electrodiagnostic pattern approach for childhood polyneuropathies. Pediatr Neurol 35:11–17CrossRefPubMedGoogle Scholar
  15. 15.
    Head KA (2006) Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev 11:294–329PubMedGoogle Scholar
  16. 16.
    Delaney CA, Mouser JV, Westerman RA (1994) Insulin sensitivity and sensory nerve function in non-diabetic human subjects. Neurosci Lett 180:277–280CrossRefPubMedGoogle Scholar
  17. 17.
    Dorfman LJ, Robinson LR (1997) AAEM minimonograph #47: normative data in electrodiagnostic medicine. ff. Muscle Nerve 20:4–14CrossRefPubMedGoogle Scholar
  18. 18.
    Buschbacher RM (1998) Body mass index effect on common nerve conduction study measurements. Muscle Nerve 21:1398–1404CrossRefPubMedGoogle Scholar
  19. 19.
    Miscio G, Guastamacchia G, Brunani A, Priano L, Baudo S, Mauro A (2005) Obesity and peripheral neuropathy risk: a dangerous liaison. J Peripher Nerv Syst 10:354–358CrossRefPubMedGoogle Scholar
  20. 20.
    Karsidag S, Morali S, Sargin M, Salman S, Karsidag K, Us O (2005) The electrophysiological findings of subclinical neuropathy in patients with recently diagnosed type 1 diabetes mellitus. Diabetes Res Clin Pract 67:211–219CrossRefPubMedGoogle Scholar
  21. 21.
    Han L, Ji L, Chang J, Wen J, Zhao W, Shi H, Zhou L, Li Y, Hu R, Hu J, Lu B (2015) Peripheral neuropathy is associated with insulin resistance independent of metabolic syndrome. Diabetol Metab Syndr 7:14CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Plastino M, Fava A, Carmela C, De Bartolo M, Ermio C, Cristiano D, Ettore M, Abenavoli L, Bosco D (2011) Insulin resistance increases risk of carpal tunnel syndrome: a case-control study. J Peripher Nerv Syst 16:186–190CrossRefPubMedGoogle Scholar
  23. 23.
    Lee KO, Nam JS, Ahn CW, Hong JM, Kim SM, Sunwoo IN, Moon JS, Na SJ, Choi YC (2012) Insulin resistance is independently associated with peripheral and autonomic neuropathy in Korean type 2 diabetic patients. Acta Diabetol 49:97–103CrossRefPubMedGoogle Scholar
  24. 24.
    Nguyen VA, Le T, Tong M, Mellion M, Gilchrist J, de la Monte SM (2012) Experimental alcohol-related peripheral neuropathy: role of insulin/IGF resistance. Nutrients 4:1042–1057CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Grote CW, Groover AL, Ryals JM, Geiger PC, Feldman EL, Wright DE (2013) Peripheral nervous system insulin resistance in ob/ob mice. Acta Neuropathol Commun 1:15CrossRefPubMedPubMedCentralGoogle Scholar
  26. 26.
    Akin O, Arslan M, Akgun H, Yavuz ST, Sari E, Tascilar ME, Ulas UH, Yesilkaya E, Unay B (2016) Visual and brainstem auditory evoked potentials in children with obesity. Brain Dev 38:310–316CrossRefPubMedGoogle Scholar
  27. 27.
    Ishii DN (2001) Neurobiology of insulin and insulin-like growth factors. In: Loughlin SE, Fallon JH (eds) Neurotrophic Factors. Academic Press, New York, pp. 415–442Google Scholar
  28. 28.
    Okabayashi Y, Maddux BA, McDonald AR, Logsdon CD, Williams JA, Goldfine ID (1989) Mechanisms of insulin-induced insulin-receptor downregulation. Decrease of receptor biosynthesis and mRNA levels. Diabetes 38:182–187CrossRefPubMedGoogle Scholar
  29. 29.
    Johnsen B, Fuglsang-Frederiksen A (2000) Electrodiagnosis of polyneuropathy. Neurophysiol Clin 30:339–351CrossRefPubMedGoogle Scholar
  30. 30.
    Cali AM, Caprio S (2008) Obesity in children and adolescents. J Clin Endocrinol Metab 93:S31–S36CrossRefPubMedPubMedCentralGoogle Scholar
  31. 31.
    Gregori B, Galie E, Pro S, Clementi A, Accornero N (2006) Luminance and chromatic visual evoked potentials in type I and type II diabetes: relationships with peripheral neuropathy. Neurol Sci 27:323–327CrossRefPubMedGoogle Scholar
  32. 32.
    Ziegler D, Langen KJ, Herzog H, Kuwert T, Muhlen H, Feinendegen LE, Gries FA (1994) Cerebral glucose metabolism in type 1 diabetic patients. Diabet Med 11:205–209CrossRefPubMedGoogle Scholar
  33. 33.
    Sumner CJ, Sheth S, Griffin JW, Cornblath DR, Polydefkis M (2003) The spectrum of neuropathy in diabetes and impaired glucose tolerance. Neurology 60:108–111CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Onur Akın
    • 1
    Email author
  • İbrahim Eker
    • 2
  • Mutluay Arslan
    • 3
  • Serdar Taşdemir
    • 4
  • Mehmet Emre Taşçılar
    • 1
  • Ümit Hıdır Ulaş
    • 4
  • Ediz Yeşilkaya
    • 1
  • Bülent Ünay
    • 3
  1. 1.Department of Pediatric EndocrinologyGülhane Military Medical AcademyAnkaraTurkey
  2. 2.Department of PediatricsGülhane Military Medical AcademyAnkaraTurkey
  3. 3.Department of Pediatric NeurologyGülhane Military Medical AcademyAnkaraTurkey
  4. 4.Department of NeurologyGülhane Military Medical AcademyAnkaraTurkey

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