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Child's Nervous System

, Volume 32, Issue 2, pp 351–353 | Cite as

Histological study of the occipital bone from patients with Chiari I malformation

  • R. Shane TubbsEmail author
  • Annie Laurie Benzie
  • Elias Rizk
  • Joshua J. Chern
  • Marios Loukas
  • W. Jerry Oakes
Original Paper

Abstract

Background

This study is focused on the histologic characteristics of occipital bone removed during Chiari I decompression in the hope of discovering unique features that may be related to the pathogenesis of this condition.

Methods

Ten consecutive pediatric patients with Chiari I malformation underwent standard posterior fossa decompression surgery. Bone that was removed from the posterior fossa was sent for histological examination. Bone from age-matched controls also underwent histological analysis.

Results

For all study and control specimens, bony samples were found to be made up of dense lamellar bone without marrow elements. In all aspects, histologically, the bone tissue had a normal appearance compared to control samples.

Conclusions

Although many authors have mentioned that the occipital bone in patients with Chiari I malformation is abnormal on imaging or at operation (e.g., thinned, thickened), based on our study, there is no histological difference between the occipital bone removed at operation and controls.

Keywords

Skull Development Embryology Posterior fossa Hindbrain hernia 

Notes

Conflict of interest

The authors have no conflicts of interest to report.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • R. Shane Tubbs
    • 1
    • 7
    Email author
  • Annie Laurie Benzie
    • 2
  • Elias Rizk
    • 3
  • Joshua J. Chern
    • 4
  • Marios Loukas
    • 5
  • W. Jerry Oakes
    • 6
  1. 1.Seattle Science FoundationSeattleUSA
  2. 2.Department of SurgeryNew York Methodist HospitalBrooklynUSA
  3. 3.Neurological SurgeryPenn State Hershey Medical CenterHersheyUSA
  4. 4.Pediatric Neurosurgery AssociatesChildren’s Healthcare of AtlantaAtlantaUSA
  5. 5.Department of Anatomical SciencesSt. George’s UniversitySt. George’sGrenada
  6. 6.Pediatric NeurosurgeryChildren’s of AlabamaBirminghamUSA
  7. 7.BirminghamUSA

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