Histological study of the occipital bone from patients with Chiari I malformation
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This study is focused on the histologic characteristics of occipital bone removed during Chiari I decompression in the hope of discovering unique features that may be related to the pathogenesis of this condition.
Ten consecutive pediatric patients with Chiari I malformation underwent standard posterior fossa decompression surgery. Bone that was removed from the posterior fossa was sent for histological examination. Bone from age-matched controls also underwent histological analysis.
For all study and control specimens, bony samples were found to be made up of dense lamellar bone without marrow elements. In all aspects, histologically, the bone tissue had a normal appearance compared to control samples.
Although many authors have mentioned that the occipital bone in patients with Chiari I malformation is abnormal on imaging or at operation (e.g., thinned, thickened), based on our study, there is no histological difference between the occipital bone removed at operation and controls.
KeywordsSkull Development Embryology Posterior fossa Hindbrain hernia
Conflict of interest
The authors have no conflicts of interest to report.
- 7.Menkes JH, Samat HB and Bernard ML, editors (2005) Child neurology, 7th Edition. 299–300Google Scholar
- 11.Shoja MM, Tubbs RS, Oakes WJ (2013) Embryology and pathophysiology of the Chiari I and II malformations in the Chiari Malformations Tubbs RS, Oakes WJ (eds). Springer Science and Business Media, New York, pp 13–54Google Scholar
- 13.Tubbs RS, Webb D, Abdullatiff H, Conklin M, Doyle S, Oakes WJ (2004) Posterior cranial fossa volume in patients with rickets: insights into the increased occurrence of Chiari I malformation in metabolic bone disease. Neurosurgery 55:383–384Google Scholar