Prevalence of resistant occipital lobe epilepsy associated with celiac disease in children
Celiac disease (CD) is a chronic, inflammatory autoimmune disorder caused by intolerance to ingested gluten. Increased frequency of CD has been reported in occipital lobe epilepsy. The aim of the present study is to investigate the frequency of CD among children followed up due to epilepsy and diagnosed with epileptic activity in the occipital lobe in at least one electroencephalography (EEG) test.
For this research, 90 pediatric epilepsy patients with epileptic activity in the occipital lobe were enrolled in the study group, while the control group comprised of 100 healthy children. In addition to the EEG examination, tissue transglutaminase (tTG) antibody was determined on duodenal biopsy.
None of the healthy children in the control group was positive in terms of the tTG antibody test used to scan CD. In the group with epileptic activity in the occipital lobe, two patients out of 90 were tTG antibody positive. The seroprevalence was 1/45 (2.22 %) in this group. These two patients were diagnosed with CD based on the endoscopic duodenal biopsy. In these patients, the seizures were uncontrollable through monotherapy.
Our results showed that the prevalence of CD is observed to be higher than the normal population among the patients with occipital lobe epilepsy. This type of seizure disorder seems to be more resistant to monotherapy, compared with other types of occipital epilepsy. Therefore, screening for CD is recommended in children with resistant epileptic activity in the occipital lobe.
KeywordsCeliac disease Occipital lobe epilepsy Prevalence Resistant
- 9.Dursun I, Dalgıc B, Elmas C, Serdaroglu A, Dursun A (2005) Silent celiac disease in epileptic children. Turk Klin J Pediatr 14:126–132Google Scholar
- 17.Labate A, Gambardella A, Messina D, Tammaro S, Le Piane E, Pirritano D, Cosco C, Doldo P, Mazzei R, Oliveri RL, Bosco D, Zappia M, Valentino P, Aguglia U, Quattrone A (2001) Silent celiac disease in patients with childhood localization-related epilepsies. Epilepsia 42:1153–1155PubMedCrossRefGoogle Scholar
- 30.Sammaritano M, Andermann F, Melanason D, Guberman A, Tinuper P, Gastaut H (1988) The syndrome of intractable epilepsy, bilateral calcifications and folic acid deficiency. Neurology 38(Suppl 1):239Google Scholar
- 31.Tutor-Crespo MJ, Hermida J, Tutor JC (2007) Relation of blood platelet count during carbamazepine and oxcarbazepine treatment with daily dose, and serum concentrations of carbamazepine, carbamazepine-10, 11-epoxide, and 10-hydroxycarbazepine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 151:91–94PubMedCrossRefGoogle Scholar
- 33.Villalta D, Alessio MG, Tampoia M, Tonutti E, Brusca I, Bagnasco M, Pesce G, Stella S, Bizzaro N (2007) Testing for IgG class antibodies in celiac disease patients with selective IgA deficiency. A comparison of the diagnostic accuracy of 9 IgG anti-tissue transglutaminase, 1 IgG anti-gliadin and 1 IgG anti-deaminated gliadin peptide antibody assays. Clin Chim Acta 382:95–99PubMedCrossRefGoogle Scholar